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Güllü Topal Görgün
Güllü Topal Görgün
Executive Director, Sr.Global Project Leader, Hematology AstraZeneca, Waltham, MA, USA
Verified email at astrazeneca.com - Homepage
Title
Cited by
Cited by
Year
Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
AG Ramsay, AJ Johnson, AM Lee, G Gorgün, R Le Dieu, W Blum, JC Byrd, ...
The Journal of clinical investigation 118 (7), 2427-2437, 2008
6832008
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma
N Mimura, M Fulciniti, G Gorgun, YT Tai, D Cirstea, L Santo, Y Hu, ...
Blood, The Journal of the American Society of Hematology 119 (24), 5772-5781, 2012
4052012
Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans
GT Görgün, G Whitehill, JL Anderson, T Hideshima, C Maguire, ...
Blood, The Journal of the American Society of Hematology 121 (15), 2975-2987, 2013
3682013
Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells
G Görgün, TAW Holderried, D Zahrieh, D Neuberg, JG Gribben
The Journal of clinical investigation 115 (7), 1797-1805, 2005
3402005
Targeting the bone marrow microenvironment in multiple myeloma
Y Kawano, M Moschetta, S Manier, S Glavey, GT Görgün, AM Roccaro, ...
Immunological reviews 263 (1), 160-172, 2015
3112015
Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple MyelomaLenalidomide in Combination with Checkpoint Blockade in Multiple Myeloma
G Görgün, MK Samur, KB Cowens, S Paula, G Bianchi, JE Anderson, ...
Clinical cancer research 21 (20), 4607-4618, 2015
2832015
A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma
G Görgün, E Calabrese, T Hideshima, J Ecsedy, G Perrone, M Mani, ...
Blood, The Journal of the American Society of Hematology 115 (25), 5202-5213, 2010
2832010
PI3K/p110δ is a novel therapeutic target in multiple myeloma
H Ikeda, T Hideshima, M Fulciniti, G Perrone, N Miura, H Yasui, Y Okawa, ...
Blood, The Journal of the American Society of Hematology 116 (9), 1460-1468, 2010
2592010
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma
G Görgün, E Calabrese, E Soydan, T Hideshima, G Perrone, M Bandi, ...
Blood, The Journal of the American Society of Hematology 116 (17), 3227-3237, 2010
2272010
Immunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host disease
G Gorgun, KB Miller, FM Foss
Blood, The Journal of the American Society of Hematology 100 (3), 941-947, 2002
2162002
Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple …
D Cirstea, T Hideshima, S Rodig, L Santo, S Pozzi, S Vallet, H Ikeda, ...
Molecular cancer therapeutics 9 (4), 963-975, 2010
1812010
Eμ-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
G Gorgun, AG Ramsay, TAW Holderried, D Zahrieh, R Le Dieu, F Liu, ...
Proceedings of the National Academy of Sciences 106 (15), 6250-6255, 2009
1442009
Ascorbic acid inhibits antitumor activity of bortezomib in vivo
G Perrone, T Hideshima, H Ikeda, Y Okawa, E Calabrese, G Gorgun, ...
Leukemia 23 (9), 1679-1686, 2009
1402009
AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition
L Santo, S Vallet, T Hideshima, D Cirstea, H Ikeda, S Pozzi, K Patel, ...
Oncogene 29 (16), 2325-2336, 2010
1352010
AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition
L Santo, S Vallet, T Hideshima, D Cirstea, H Ikeda, S Pozzi, K Patel, ...
Oncogene 29 (16), 2325-2336, 2010
1352010
Histone deacetylase 3 as a novel therapeutic target in multiple myeloma
J Minami, R Suzuki, R Mazitschek, G Gorgun, B Ghosh, D Cirstea, Y Hu, ...
Leukemia 28 (3), 680-689, 2014
1322014
Aurora kinase A is a target of Wnt/β-catenin involved in multiple myeloma disease progression
J Dutta-Simmons, Y Zhang, G Gorgun, M Gatt, M Mani, T Hideshima, ...
Blood, The Journal of the American Society of Hematology 114 (13), 2699-2708, 2009
1252009
Immunomodulatory effects of extracorporeal photochemotherapy in patients with extensive chronic graft-versus-host disease
T Alcindor, G Gorgun, KB Miller, TF Roberts, K Sprague, DP Schenkein, ...
Blood, The Journal of the American Society of Hematology 98 (5), 1622-1625, 2001
1242001
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma
T Hideshima, J Qi, RM Paranal, W Tang, E Greenberg, N West, ...
Proceedings of the National Academy of Sciences 113 (46), 13162-13167, 2016
1072016
Extracorporeal photopheresis in chronic graft-versus-host disease
FM Foss, G Gorgun, KB Miller
Bone marrow transplantation 29 (9), 719-725, 2002
1072002
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