Morris F White

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1986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025245 314 463 626 583 697 876 1184 1552 1700 1829 2059 2254 2078 2001 2325 2361 2155 2512 2860 2636 2874 2867 2915 2801 2832 3081 3008 3021 2745 2657 2411 2376 2105 2101 2254 1982 1884 1614 355

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C. Ronald KahnJoslin Diabetes Center and Harvard Medical SchoolVerified email at joslin.harvard.edu
Martin MyersUniversity of MichiganVerified email at umich.edu
Xiao Jian SunThe University of MarylandVerified email at medicine.umaryland.edu
Lynne YenushProfesor Departamento de Biotecnología Universidad Politécnica de ValenciaVerified email at ibmcp.upv.es
Steven ShoelsonHarvard Medical SchoolVerified email at joslin.harvard.edu
Gerald I ShulmanYale School of Medicine/Howard Hughes Medical InstituteVerified email at yale.edu
Sebastian PonsInstituto de Biología Molecular de BarcelonaVerified email at ibmb.csic.es
Zhiyong ChengUniversity of FloridaVerified email at ufl.edu
Shaodong GuoTexas A&M University, College Station, Texas USAVerified email at tamu.edu
Barry J. GoldsteinVice President and Therapeutic Area Head, Covance, IncVerified email at covance.com
Bruce M. SpiegelmanStanley J. Korsmeyer Professor, Harvard Medical School and Dana-Farber Cancer InstituteVerified email at dfci.harvard.edu
Hans-Ulrich HäringProfessor of Endocrinology and DiabetologyVerified email at med.uni-tuebingen.de
Liangyou RuiLouis G. D'Alecy Collegiate Professor of Physiology, University of Michigan Medical SchoolVerified email at umich.edu
Marianna SadagurskiWayne State UniversityVerified email at wayne.edu
X. Charlie DongIndiana University School of MedicineVerified email at iu.edu
John BlenisProfessor of Pharmacology, Weill Cornell MedicineVerified email at med.cornell.edu
Stephen PrevisMerckVerified email at merck.com
Joseph SchlessingerYale university School of MedicineVerified email at Yale.edu
Susan Bonner-Weir , Susan Bonner W...Joslin Diabetes Center, Harvard Medical SchoolVerified email at joslin.harvard.edu
Sunmin ParkHoseo UniversityVerified email at hoseo.edu

Morris F White

Professor of Pediatrics, Harvard Medical School

Verified email at childrens.harvard.edu - Homepage

insulin action insulin diabetes


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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance GS Hotamisligil, P Peraldi, A Budavari, R Ellis, MF White, BM Spiegelman Science 271 (5249), 665-670, 1996	3744	1996
Disruption of IRS-2 causes type 2 diabetes in mice DJ Withers, JS Gutierrez, H Towery, DJ Burks, JM Ren, S Previs, Y Zhang, ... Nature 391 (6670), 900-904, 1998	2154	1998
The insulin signaling system. MF White, CR Kahn Journal of Biological Chemistry 269 (1), 1-4, 1994	2112	1994
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein XJ Sun, P Rothenberg, CR Kahn, JM Backer, E Araki, PA Wilden, ... Nature 352 (6330), 73-77, 1991	2066	1991
The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307 V Aguirre, T Uchida, L Yenush, R Davis, MF White Journal of Biological Chemistry 275 (12), 9047-9054, 2000	1991	2000
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle C Yu, Y Chen, GW Cline, D Zhang, H Zong, Y Wang, R Bergeron, JK Kim, ... Journal of Biological Chemistry 277 (52), 50230-50236, 2002	1974	2002
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, ... Diabetes 48 (6), 1270-1274, 1999	1735	1999
IRS proteins and the common path to diabetes MF White American Journal of Physiology-Endocrinology and Metabolism 283 (3), E413-E422, 2002	1337	2002
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action V Aguirre, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White Journal of biological chemistry 277 (2), 1531-1537, 2002	1306	2002
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 L Rui, M Yuan, D Frantz, S Shoelson, MF White Journal of Biological Chemistry 277 (44), 42394-42398, 2002	1206	2002
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 KD Copps, MF White Diabetologia 55, 2565-2582, 2012	1189	2012
Role of IRS-2 in insulin and cytokine signalling XJ Sun, LM Wang, Y Zhang, L Yenush, MG Myers Jr, E Glasheen, ... Nature 377 (6545), 173-177, 1995	1175	1995
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents K Morino, KF Petersen, S Dufour, D Befroy, J Frattini, N Shatzkes, ... The Journal of clinical investigation 115 (12), 3587-3593, 2005	1050	2005
The IRS-signalling system: a network of docking proteins that mediate insulin action MF White Insulin Action, 3-11, 1998	1014	1998
Insulin signaling in health and disease MF White Science 302 (5651), 1710-1711, 2003	960	2003
Insulin rapidly stimulates tyrosine phosphorylation of a M_r-185,000 protein in intact cells MF White, R Maron, CR Kahn Nature 318 (6042), 183-186, 1985	880	1985
The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EY Skolnik, CH Lee, A Batzer, LM Vicentini, M Zhou, R Daly, MJ Myers Jr, ... The EMBO journal 12 (5), 1929-1936, 1993	876	1993
The insulin signalling system and the IRS proteins MF White Diabetologia 40, S2-S17, 1997	805	1997
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats ZY Jiang, YW Lin, A Clemont, EP Feener, KD Hein, M Igarashi, ... The Journal of clinical investigation 104 (4), 447-457, 1999	798	1999
Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser³⁰⁷ via distinct pathways L Rui, V Aguirre, JK Kim, GI Shulman, A Lee, A Corbould, A Dunaif, ... The Journal of clinical investigation 107 (2), 181-189, 2001	795	2001

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