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Keshav Gopal
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Lipotoxicity in obesity and diabetes-related cardiac dysfunction
I Zlobine, K Gopal, JR Ussher
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2016
1672016
Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency
KL Ho, L Zhang, C Wagg, R Al Batran, K Gopal, J Levasseur, T Leone, ...
Cardiovascular research 115 (11), 1606-1616, 2019
1462019
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
GM Uddin, L Zhang, S Shah, A Fukushima, CS Wagg, K Gopal, ...
Cardiovascular diabetology 18, 1-12, 2019
1222019
FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression
K Gopal, B Saleme, R Al Batran, H Aburasayn, A Eshreif, KL Ho, WK Ma, ...
American Journal of Physiology-Heart and Circulatory Physiology 313 (3 …, 2017
632017
Inactivation of the glucose-dependent insulinotropic polypeptide receptor improves outcomes following experimental myocardial infarction
JR Ussher, JE Campbell, EE Mulvihill, LL Baggio, HE Bates, BA McLean, ...
Cell metabolism 27 (2), 450-460. e6, 2018
622018
Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity
B Saleme, V Gurtu, Y Zhang, A Kinnaird, AE Boukouris, K Gopal, ...
Science translational medicine 11 (478), eaau8866, 2019
602019
The opposing function of STAT3 as an oncoprotein and tumor suppressor is dictated by the expression status of STAT3β in esophageal squamous cell carcinoma
HF Zhang, Y Chen, C Wu, ZY Wu, DJ Tweardy, A Alshareef, LD Liao, ...
Clinical Cancer Research 22 (3), 691-703, 2016
572016
Identification and modeling of a drug target for Clostridium perfringens SM101
G Chhabra, P Sharma, A Anant, S Deshmukh, H Kaushik, K Gopal, ...
Bioinformation 4 (7), 278, 2010
472010
Pimozide alleviates hyperglycemia in diet-induced obesity by inhibiting skeletal muscle ketone oxidation
R Al Batran, K Gopal, ME Capozzi, JJ Chahade, B Saleme, ...
Cell Metabolism 31 (5), 909-919. e8, 2020
462020
The GLP-1 receptor agonist liraglutide increases myocardial glucose oxidation rates via indirect mechanisms and mitigates experimental diabetic cardiomyopathy
M Almutairi, K Gopal, AA Greenwell, A Young, R Gill, H Aburasayn, ...
Canadian Journal of Cardiology 37 (1), 140-150, 2021
422021
β-Catenin, a Sox2 binding partner, regulates the DNA binding and transcriptional activity of Sox2 in breast cancer cells
X Ye, F Wu, C Wu, P Wang, K Jung, K Gopal, Y Ma, L Li, R Lai
Cellular signalling 26 (3), 492-501, 2014
382014
Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter
K Gopal, N Gupta, H Zhang, A Alshareef, H Alqahtani, G Bigras, J Lewis, ...
Oncotarget 7 (3), 3111, 2016
372016
Hypoxia induces the acquisition of cancer stem-like phenotype via upregulation and activation of signal transducer and activator of transcription-3 (STAT3) in MDA-MB-231, a …
H Soleymani Abyaneh, N Gupta, A Alshareef, K Gopal, A Lavasanifar, ...
Cancer Microenvironment 11, 141-152, 2018
362018
Cardiac-specific deletion of pyruvate dehydrogenase impairs glucose oxidation rates and induces diastolic dysfunction
K Gopal, M Almutairi, R Al Batran, F Eaton, M Gandhi, JR Ussher
Frontiers in Cardiovascular Medicine 5, 17, 2018
332018
DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer
H Alqahtani, K Gopal, N Gupta, K Jung, A Alshareef, X Ye, F Wu, L Li, ...
Cellular signalling 28 (2), 42-50, 2016
322016
FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity
K Gopal, R Al Batran, TR Altamimi, AA Greenwell, CT Saed, SAT Dakhili, ...
Cell Reports 35 (1), 2021
312021
Myocardial energy metabolism in non-ischemic cardiomyopathy
AA Greenwell, K Gopal, JR Ussher
Frontiers in Physiology 11, 570421, 2020
282020
STAT1 is phosphorylated and downregulated by the oncogenic tyrosine kinase NPM-ALK in ALK-positive anaplastic large-cell lymphoma
C Wu, O Molavi, H Zhang, N Gupta, A Alshareef, KM Bone, K Gopal, F Wu, ...
Blood, The Journal of the American Society of Hematology 126 (3), 336-345, 2015
282015
Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter
K Jung, N Gupta, P Wang, JT Lewis, K Gopal, F Wu, X Ye, A Alshareef, ...
Oncotarget 6 (12), 10366, 2015
272015
Biochemical and functional characterization of UDP-galactose 4-epimerase from Aeromonas hydrophila
S Agarwal, K Gopal, T Upadhyaya, A Dixit
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (7), 828-837, 2007
252007
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