| Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination JSL Yu, W Cui Development 143 (17), 3050-3060, 2016 | 974 | 2016 |
| Ultra-fast proteomics with Scanning SWATH CB Messner, V Demichev, N Bloomfield, JSL Yu, M White, M Kreidl, ... Nature biotechnology 39 (7), 846-854, 2021 | 210 | 2021 |
| Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism V Olin-Sandoval, JSL Yu, L Miller-Fleming, MT Alam, S Kamrad, ... Nature 572 (7768), 249-253, 2019 | 113 | 2019 |
| PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation JSL Yu, TS Ramasamy, N Murphy, MK Holt, R Czapiewski, SK Wei, W Cui Nature communications 6 (1), 7212, 2015 | 102 | 2015 |
| Genome-wide CRISPR-KO screen uncovers mTORC1-mediated Gsk3 regulation in naive pluripotency maintenance and dissolution M Li, SL Jason, K Tilgner, SH Ong, H Koike-Yusa, K Yusa Cell reports 24 (2), 489-502, 2018 | 87 | 2018 |
| Application of three-dimensional culture conditions to human embryonic stem cell-derived definitive endoderm cells enhances hepatocyte differentiation and functionality TS Ramasamy, JSL Yu, C Selden, H Hodgson, W Cui Tissue Engineering Part A 19 (3-4), 360-367, 2013 | 80 | 2013 |
| Genome-wide CRISPR-Cas9 screening in mammalian cells SL Jason, K Yusa Methods 164, 29-35, 2019 | 70 | 2019 |
| Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance JSL Yu, C Correia-Melo, F Zorrilla, L Herrera-Dominguez, MY Wu, J Hartl, ... Nature microbiology 7 (4), 542-555, 2022 | 58 | 2022 |
| Identification and characterisation of the early differentiating cells in neural differentiation of human embryonic stem cells P Noisa, TS Ramasamy, FR Lamont, JSL Yu, MJ Sheldon, A Russell, ... PloS one 7 (5), e37129, 2012 | 50 | 2012 |
| TRF2-mediated stabilization of hREST4 is critical for the differentiation and maintenance of neural progenitors P Ovando-Roche, JSL Yu, S Testori, C Ho, W Cui Stem Cells 32 (8), 2111-2122, 2014 | 40 | 2014 |
| The metabolic growth limitations of petite cells lacking the mitochondrial genome J Vowinckel, J Hartl, H Marx, M Kerick, K Runggatscher, MA Keller, ... Nature metabolism 3 (11), 1521-1535, 2021 | 30 | 2021 |
| KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements YZ Au, M Gu, E De Braekeleer, M Gozdecka, D Aspris, Y Tarumoto, ... Leukemia 35 (4), 1012-1022, 2021 | 29 | 2021 |
| Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan C Correia-Melo, S Kamrad, R Tengölics, CB Messner, P Trebulle, ... Cell 186 (1), 63-79. e21, 2023 | 24 | 2023 |
| CRISPR-knockout screen identifies Dmap1 as a regulator of chemically induced reprogramming and differentiation of cardiac progenitors JSL Yu, G Palano, C Lim, A Moggio, L Drowley, AT Plowright, ... Stem Cells 37 (7), 958-972, 2019 | 14 | 2019 |
| Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy JSL Yu, BM Heineike, J Hartl, SK Aulakh, C Correia-Melo, A Lehmann, ... Plos Biology 20 (12), e3001912, 2022 | 5 | 2022 |
| KAT7 is a therapeutic vulnerability of MLL-rearranged acute myeloid leukemia YZ Au, M Gu, E De Braekeleer, J Yu, SH Ong, M Gozdecka, X Chen, ... bioRxiv, 2020.04. 25.054049, 2020 | | 2020 |
| Genome-wide CRISPR screens identify combination strategies for Capivasertib (AZD5363; AKT) and AZD8186 (PI3K13/6) in PTENnull breast cancer S Dunn, J Yu, A Gris-Oliver, J Pilling, P Hoperoft, U Yelland, N Cureton, ... CANCER RESEARCH 79 (13), 2019 | | 2019 |
| Genome-wide CRISPR screens identify combination strategies for Capivasertib (AZD5363; AKT) and AZD8186 (PI3Kβ/δ) in PTEN-null breast cancer S Dunn, J Yu, A Gris-Oliver, J Pilling, P Hopcroft, U Yelland, N Cureton, ... Cancer Research 79 (13_Supplement), 321-321, 2019 | | 2019 |
| Robust differentiation of human embryonic stem cells into definitive endoderm using Activin A coupled with mTOR inhibition. J Yu, W Cui Nature Protocols, 2015 | | 2015 |
| Mechanistic characterisation of Activin/Smad and PI3K/mTOR crosstalk during the specification of definitive endoderm from human embryonic stem cells JSL Yu Imperial College London, 2015 | | 2015 |
Kosuke YusaProfessor, Kyoto UniversityVerified email at infront.kyoto-u.ac.jp
