Brian Hie
Brian Hie
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Cited by
Cited by
Evolutionary-scale prediction of atomic-level protein structure with a language model
Z Lin, H Akin, R Rao, B Hie, Z Zhu, W Lu, N Smetanin, R Verkuil, O Kabeli, ...
Science 379 (6637), 1123-1130, 2023
Efficient integration of heterogeneous single-cell transcriptomes using Scanorama
B Hie, B Bryson, B Berger
Nature Biotechnology 37 (6), 685-691, 2019
Learning inverse folding from millions of predicted structures
C Hsu, R Verkuil, J Liu, Z Lin, B Hie, T Sercu, A Lerer, A Rives
International Conference on Machine Learning, 8946-8970, 2022
Learning the language of viral evolution and escape
B Hie, ED Zhong, B Berger, B Bryson
Science 371 (6526), 284-288, 2021
Efficient evolution of human antibodies from general protein language models
BL Hie, VR Shanker, D Xu, TUJ Bruun, PA Weidenbacher, S Tang, W Wu, ...
Nature Biotechnology, 1-9, 2023
Predicting the mutational drivers of future SARS-CoV-2 variants of concern
MC Maher, I Bartha, S Weaver, J Di Iulio, E Ferri, L Soriaga, FA Lempp, ...
Science Translational Medicine 14 (633), eabk3445, 2022
Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design
B Hie, BD Bryson, BA Berger
Cell Systems 11 (5), 461-477.e9, 2020
Pooled ChIP-seq links variation in transcription factor binding to complex disease risk
AK Tehranchi, M Myrthil, T Martin, BL Hie, D Golan, HB Fraser
Cell 165 (3), 730-741, 2016
Geometric sketching compactly summarizes the single-cell transcriptomic landscape
B Hie, H Cho, B DeMeo, B Bryson, B Berger
Cell Systems 8 (6), 483-493. e7, 2019
Computational Methods for Single-Cell RNA Sequencing
B Hie, J Peters, SK Nyquist, AK Shalek, B Berger, BD Bryson
Annual Review of Biomedical Data Science 3, 2020
Evolutionary velocity with protein language models predicts evolutionary dynamics of diverse proteins
BL Hie, KK Yang, PS Kim
Cell Systems 13 (4), 274-285. e6, 2022
Adaptive machine learning for protein engineering
BL Hie, KK Yang
Current Opinion in Structural Biology 72, 145-152, 2022
Fine-mapping cis-regulatory variants in diverse human populations
A Tehranchi, B Hie, M Dacre, I Kaplow, K Pettie, P Combs, HB Fraser
eLife 8, e39595, 2019
Realizing private and practical pharmacological collaboration
B Hie, H Cho, B Berger
Science 362 (6412), 347-350, 2018
Schema: metric learning enables interpretable synthesis of heterogeneous single-cell modalities
R Singh, BL Hie, A Narayan, B Berger
Genome Biology 22 (1), 131, 2021
A high-level programming language for generative protein design
B Hie, S Candido, Z Lin, O Kabeli, R Rao, N Smetanin, T Sercu, A Rives
bioRxiv, 2022.12. 21.521526, 2022
Sequence modeling and design from molecular to genome scale with Evo
E Nguyen, M Poli, MG Durrant, AW Thomas, B Kang, J Sullivan, MY Ng, ...
bioRxiv, 2024.02. 27.582234, 2024
Mechanistic Design and Scaling of Hybrid Architectures
M Poli, AW Thomas, E Nguyen, P Ponnusamy, B Deiseroth, K Kersting, ...
arXiv preprint arXiv:2403.17844, 2024
Coexpression enables multi-study cellular trajectories of development and disease
B Hie, H Cho, B Bryson, B Berger
bioRxiv, 719088, 2020
Unsupervised evolution of protein and antibody complexes with a structure-informed language model
VR Shanker, TUJ Bruun, BL Hie, PS Kim
Science 385 (6704), 46-53, 2024
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