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Lindsey Richelle Fernandez Backman
Lindsey Richelle Fernandez Backman
Valhalla Fellow, Whitehead Institute for Biomedical Research
Verified email at mit.edu - Homepage
Title
Cited by
Cited by
Year
New tricks for the glycyl radical enzyme family
LRF Backman, MA Funk, CD Dawson, CL Drennan
Critical reviews in biochemistry and molecular biology 52 (6), 674-695, 2017
832017
Oxidative stress shapes breast cancer phenotype through chronic activation of ATM-dependent signaling
M Alpay, LRF Backman, X Cheng, M Dukel, WJ Kim, L Ai, KD Brown
Breast cancer research and treatment 151, 75-87, 2015
452015
The breast cancer tumor suppressor TRIM29 is expressed via ATM-dependent signaling in response to hypoxia
M Dükel, WS Streitfeld, TCC Tang, LRF Backman, L Ai, WS May, ...
Journal of Biological Chemistry 291 (41), 21541-21552, 2016
312016
Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme
LRF Backman, YY Huang, MC Andorfer, B Gold, RT Raines, EP Balskus, ...
elife 9, e51420, 2020
172020
Molecular basis of CS bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase
CD Dawson, SM Irwin, LRF Backman, C Le, JX Wang, V Vennelakanti, ...
Cell Chemical Biology 28 (9), 1333-1346. e7, 2021
152021
Solution structure and biochemical characterization of a spare part protein that restores activity to an oxygen-damaged glycyl radical enzyme
SEJ Bowman, LRF Backman, RE Bjork, MC Andorfer, S Yori, A Caruso, ...
JBIC Journal of Biological Inorganic Chemistry 24, 817-829, 2019
122019
Rescuing activity of oxygen-damaged pyruvate formate-lyase by a spare part protein
MC Andorfer, LRF Backman, PL Li, EC Ulrich, CL Drennan
Journal of Biological Chemistry 297 (6), 2021
72021
ATM is required for SOD2 expression and homeostasis within the mammary gland
LM Dyer, JD Kepple, L Ai, WJ Kim, VL Stanton, MK Reinhard, ...
Breast cancer research and treatment 166, 725-741, 2017
72017
Abstract 1847 Capturing multiple conformations of glycyl radical enzymes found in the human gut microbiome using single particle cryoEM
C Imrich, L Backman, M Andorfer, C Drennan
Journal of Biological Chemistry 300 (3), 2024
2024
Abstract 1963 Bacterial Organelles: Encapsulation of Anaerobic Metabolic Pathways within Bacterial Microcompartments in the Human Microbiome
L Backman
Journal of Biological Chemistry 300 (3), 2024
2024
Track: Miniproteins: Are There Really That Many Additional Genes That We Have Been Missing? Is it a mistake in the genome sequencing or a spare part protein?
M Andorfer, L Backman
PROTEIN SCIENCE 32, 2023
2023
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile
LRF Backman, YY Huang, MC Andorfer, B Gold, RT Raines, EP Balskus, ...
The FASEB Journal 36, 2022
2022
Repairing enzymes using spare parts
CL Drennan, MC Andorfer, LRF Backman, PL Li, EC Ulrich
The FASEB Journal 36, 2022
2022
Structural and Biochemical Characterization of Glycyl Radical Enzymes Abundant in Mammalian Gut Microbiota
LRF Backman
Massachusetts Institute of Technology, 2022
2022
Spare Parts for Oxygen-Damaged Enzymes
M Andorfer, L Backman, S Bowman, R Bjork, E Ulrich, P Li, S Yori, ...
PROTEIN SCIENCE 30, 31-31, 2021
2021
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen C. difficile
L Backman
Acta Crystallographica Section A: Foundations and Advances 77, a4-a4, 2021
2021
Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a
LR Backman, YY Huang, MC Andorfer
2020
Mechanistic study of glycyl radical enzyme
Z Yang, H Kulik
2019 AIChE Annual Meeting, 2019
2019
Restoring activity to oxygen-damaged glycyl radical enzymes: Spare parts for proteins
M Andorfer, L Backman, S Bowman, R Bjork, P Li, S Yori, C Drennan
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257, 2019
2019
Anaerobic 4‐Hydroxyproline Metabolism by a Widespread Microbial Glycyl Radical Enzyme
YY Huang, L Backman, B Gold, RT Raines, CL Drennan, EP Balskus
The FASEB Journal 32, 534.16-534.16, 2018
2018
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