Roberto Zoncu
Roberto Zoncu
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Cited by
mTOR: from growth signal integration to cancer, diabetes and ageing
R Zoncu, A Efeyan, DM Sabatini
Nature reviews Molecular cell biology 12 (1), 21-35, 2011
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Y Sancak, L Bar-Peled, R Zoncu, AL Markhard, S Nada, DM Sabatini
Cell 141 (2), 290-303, 2010
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
K Bersuker, JM Hendricks, Z Li, L Magtanong, B Ford, PH Tang, ...
Nature 575 (7784), 688-692, 2019
A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
C Settembre, R Zoncu, DL Medina, F Vetrini, S Erdin, SU Erdin, T Huynh, ...
The EMBO journal 31 (5), 1095-1108, 2012
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase
R Zoncu, L Bar-Peled, A Efeyan, S Wang, Y Sancak, DM Sabatini
Science 334 (6056), 678-683, 2011
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
L Bar-Peled, LD Schweitzer, R Zoncu, DM Sabatini
Cell 150 (6), 1196-1208, 2012
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
G Sahay, W Querbes, C Alabi, A Eltoukhy, S Sarkar, C Zurenko, ...
Nature biotechnology 31 (7), 653-658, 2013
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
S Wang, ZY Tsun, RL Wolfson, K Shen, GA Wyant, ME Plovanich, ...
Science 347 (6218), 188-194, 2015
Origin of GABAergic neurons in the human neocortex
K Letinic, R Zoncu, P Rakic
Nature 417 (6889), 645-649, 2002
Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
RM Perera, S Stoykova, BN Nicolay, KN Ross, J Fitamant, M Boukhali, ...
Nature 524 (7565), 361-365, 2015
The lysosome as a cellular centre for signalling, metabolism and quality control
RE Lawrence, R Zoncu
Nature cell biology 21 (2), 133-142, 2019
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
ZY Tsun, L Bar-Peled, L Chantranupong, R Zoncu, T Wang, C Kim, ...
Molecular cell 52 (4), 495-505, 2013
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
P Katajisto, J Döhla, CL Chaffer, N Pentinmikko, N Marjanovic, S Iqbal, ...
Science 348 (6232), 340-343, 2015
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin
G Di Paolo, L Pellegrini, K Letinic, G Cestra, R Zoncu, S Voronov, ...
Nature 420 (6911), 85-89, 2002
The lysosome as a regulatory hub
RM Perera, R Zoncu
Annual review of cell and developmental biology 32 (1), 223-253, 2016
Amino acids and mTORC1: from lysosomes to disease
A Efeyan, R Zoncu, DM Sabatini
Trends in molecular medicine 18 (9), 524-533, 2012
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
A Efeyan, R Zoncu, S Chang, I Gumper, H Snitkin, RL Wolfson, O Kirak, ...
Nature 493 (7434), 679-683, 2013
Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
BM Castellano, AM Thelen, O Moldavski, MK Feltes, REN Van Der Welle, ...
Science 355 (6331), 1306-1311, 2017
DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy
TB Nguyen, SM Louie, JR Daniele, Q Tran, A Dillin, R Zoncu, DK Nomura, ...
Developmental cell 42 (1), 9-21. e5, 2017
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes
R Zoncu, RM Perera, DM Balkin, M Pirruccello, D Toomre, P De Camilli
Cell 136 (6), 1110-1121, 2009
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