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Lauren Drowley
Lauren Drowley
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Year
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
RJ Mills, DM Titmarsh, X Koenig, BL Parker, JG Ryall, GA Quaife-Ryan, ...
Proceedings of the National Academy of Sciences 114 (40), E8372-E8381, 2017
4202017
Prospective identification of myogenic endothelial cells in human skeletal muscle
B Zheng, B Cao, M Crisan, B Sun, G Li, A Logar, S Yap, JB Pollett, ...
Nature biotechnology 25 (9), 1025-1034, 2007
3902007
Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway
RJ Mills, BL Parker, GA Quaife-Ryan, HK Voges, EJ Needham, A Bornot, ...
Cell stem cell 24 (6), 895-907. e6, 2019
2392019
Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions
X Bao, X Lian, TA Hacker, EG Schmuck, T Qian, VJ Bhute, T Han, M Shi, ...
Nature biomedical engineering 1 (1), 0003, 2016
1072016
Cellular antioxidant levels influence muscle stem cell therapy
L Drowley, M Okada, S Beckman, J Vella, B Keller, K Tobita, J Huard
Molecular Therapy 18 (10), 1865-1873, 2010
1032010
Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase …
L Drowley, C Koonce, S Peel, A Jonebring, AT Plowright, SJ Kattman, ...
Stem cells translational medicine 5 (2), 164-174, 2016
472016
Mechanical loading of stem cells for improvement of transplantation outcome in a model of acute myocardial infarction: the role of loading history
TR Cassino, L Drowley, M Okada, SA Beckman, B Keller, K Tobita, ...
Tissue Engineering Part A 18 (11-12), 1101-1108, 2012
372012
Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells
M Ding, H Andersson, S Martinsson, A Sabirsh, A Jonebring, QD Wang, ...
Scientific reports 10 (1), 13575, 2020
352020
Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts
M Okada, TR Payne, L Drowley, RJ Jankowski, N Momoi, S Beckman, ...
Molecular Therapy 20 (1), 138-145, 2012
262012
Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level
B Zheng, G Li, WCW Chen, BM Deasy, JB Pollett, B Sun, L Drowley, ...
Journal of Orthopaedic Research 31 (7), 1089-1095, 2013
252013
High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
LA Woo, S Tkachenko, M Ding, AT Plowright, O Engkvist, H Andersson, ...
Journal of molecular and cellular cardiology 127, 204-214, 2019
242019
Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach
L Drowley, J McPheat, A Nordqvist, S Peel, U Karlsson, S Martinsson, ...
Stem cells translational medicine 9 (1), 47-60, 2020
222020
Phenotypic screen for cardiac regeneration identifies molecules with differential activity in human epicardium-derived cells versus cardiac fibroblasts
AI Paunovic, L Drowley, A Nordqvist, E Ericson, E Mouchet, A Jonebring, ...
ACS Chemical Biology 12 (1), 132-141, 2017
212017
Sex of muscle stem cells does not influence potency for cardiac cell therapy
L Drowley, M Okada, TR Payne, GP Botta, H Oshima, BB Keller, K Tobita, ...
Cell Transplantation 18 (10-11), 1137-1146, 2009
162009
CRISPR-knockout screen identifies Dmap1 as a regulator of chemically induced reprogramming and differentiation of cardiac progenitors
JSL Yu, G Palano, C Lim, A Moggio, L Drowley, AT Plowright, ...
Stem Cells 37 (7), 958-972, 2019
142019
Epigenome editing of the CFTR-locus for treatment of cystic fibrosis
AM Kabadi, L Machlin, N Dalal, RE Lee, I McDowell, NN Shah, L Drowley, ...
Journal of Cystic Fibrosis 21 (1), 164-171, 2022
92022
Applications of functional genomics for drug discovery
A Kabadi, E McDonnell, CL Frank, L Drowley
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (8), 823-842, 2020
82020
Toward Second‐Generation Cardiomyogenic and Anti‐cardiofibrotic 1, 4‐Dihydropyridine‐Class TGFβ Inhibitors
D Längle, TR Werner, F Wesseler, E Reckzeh, N Schaumann, L Drowley, ...
ChemMedChem 14 (8), 810-822, 2019
82019
Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes
D Schade, L Drowley, QD Wang, AT Plowright, B Greber
Bioorganic & Medicinal Chemistry 65, 116782, 2022
52022
Phenotypic screening
AT Plowright, L Drowley
Annual Reports in Medicinal Chemistry 50, 263-299, 2017
52017
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