Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest RJ Mills, DM Titmarsh, X Koenig, BL Parker, JG Ryall, GA Quaife-Ryan, ... Proceedings of the National Academy of Sciences 114 (40), E8372-E8381, 2017 | 420 | 2017 |
Prospective identification of myogenic endothelial cells in human skeletal muscle B Zheng, B Cao, M Crisan, B Sun, G Li, A Logar, S Yap, JB Pollett, ... Nature biotechnology 25 (9), 1025-1034, 2007 | 390 | 2007 |
Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway RJ Mills, BL Parker, GA Quaife-Ryan, HK Voges, EJ Needham, A Bornot, ... Cell stem cell 24 (6), 895-907. e6, 2019 | 239 | 2019 |
Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions X Bao, X Lian, TA Hacker, EG Schmuck, T Qian, VJ Bhute, T Han, M Shi, ... Nature biomedical engineering 1 (1), 0003, 2016 | 107 | 2016 |
Cellular antioxidant levels influence muscle stem cell therapy L Drowley, M Okada, S Beckman, J Vella, B Keller, K Tobita, J Huard Molecular Therapy 18 (10), 1865-1873, 2010 | 103 | 2010 |
Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase … L Drowley, C Koonce, S Peel, A Jonebring, AT Plowright, SJ Kattman, ... Stem cells translational medicine 5 (2), 164-174, 2016 | 47 | 2016 |
Mechanical loading of stem cells for improvement of transplantation outcome in a model of acute myocardial infarction: the role of loading history TR Cassino, L Drowley, M Okada, SA Beckman, B Keller, K Tobita, ... Tissue Engineering Part A 18 (11-12), 1101-1108, 2012 | 37 | 2012 |
Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells M Ding, H Andersson, S Martinsson, A Sabirsh, A Jonebring, QD Wang, ... Scientific reports 10 (1), 13575, 2020 | 35 | 2020 |
Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts M Okada, TR Payne, L Drowley, RJ Jankowski, N Momoi, S Beckman, ... Molecular Therapy 20 (1), 138-145, 2012 | 26 | 2012 |
Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level B Zheng, G Li, WCW Chen, BM Deasy, JB Pollett, B Sun, L Drowley, ... Journal of Orthopaedic Research 31 (7), 1089-1095, 2013 | 25 | 2013 |
High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets LA Woo, S Tkachenko, M Ding, AT Plowright, O Engkvist, H Andersson, ... Journal of molecular and cellular cardiology 127, 204-214, 2019 | 24 | 2019 |
Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach L Drowley, J McPheat, A Nordqvist, S Peel, U Karlsson, S Martinsson, ... Stem cells translational medicine 9 (1), 47-60, 2020 | 22 | 2020 |
Phenotypic screen for cardiac regeneration identifies molecules with differential activity in human epicardium-derived cells versus cardiac fibroblasts AI Paunovic, L Drowley, A Nordqvist, E Ericson, E Mouchet, A Jonebring, ... ACS Chemical Biology 12 (1), 132-141, 2017 | 21 | 2017 |
Sex of muscle stem cells does not influence potency for cardiac cell therapy L Drowley, M Okada, TR Payne, GP Botta, H Oshima, BB Keller, K Tobita, ... Cell Transplantation 18 (10-11), 1137-1146, 2009 | 16 | 2009 |
CRISPR-knockout screen identifies Dmap1 as a regulator of chemically induced reprogramming and differentiation of cardiac progenitors JSL Yu, G Palano, C Lim, A Moggio, L Drowley, AT Plowright, ... Stem Cells 37 (7), 958-972, 2019 | 14 | 2019 |
Epigenome editing of the CFTR-locus for treatment of cystic fibrosis AM Kabadi, L Machlin, N Dalal, RE Lee, I McDowell, NN Shah, L Drowley, ... Journal of Cystic Fibrosis 21 (1), 164-171, 2022 | 9 | 2022 |
Applications of functional genomics for drug discovery A Kabadi, E McDonnell, CL Frank, L Drowley SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (8), 823-842, 2020 | 8 | 2020 |
Toward Second‐Generation Cardiomyogenic and Anti‐cardiofibrotic 1, 4‐Dihydropyridine‐Class TGFβ Inhibitors D Längle, TR Werner, F Wesseler, E Reckzeh, N Schaumann, L Drowley, ... ChemMedChem 14 (8), 810-822, 2019 | 8 | 2019 |
Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes D Schade, L Drowley, QD Wang, AT Plowright, B Greber Bioorganic & Medicinal Chemistry 65, 116782, 2022 | 5 | 2022 |
Phenotypic screening AT Plowright, L Drowley Annual Reports in Medicinal Chemistry 50, 263-299, 2017 | 5 | 2017 |