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Paul Geurink
Paul Geurink
Assistant professor, LUMC
Verified email at lumc.nl
Title
Cited by
Cited by
Year
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
D Shin, R Mukherjee, D Grewe, D Bojkova, K Baek, A Bhattacharya, ...
Nature 587 (7835), 657-662, 2020
9072020
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
TET Mevissen, MK Hospenthal, PP Geurink, PR Elliott, M Akutsu, ...
Cell 154 (1), 169-184, 2013
5682013
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
T Klemm, G Ebert, DJ Calleja, CC Allison, LW Richardson, JP Bernardini, ...
The EMBO journal 39 (18), e106275, 2020
3752020
On terminal alkynes that can react with active-site cysteine nucleophiles in proteases
R Ekkebus, SI van Kasteren, Y Kulathu, A Scholten, I Berlin, PP Geurink, ...
Journal of the American Chemical Society 135 (8), 2867-2870, 2013
3392013
Rapid covalent-probe discovery by electrophile-fragment screening
E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ...
Journal of the American Chemical Society 141 (22), 8951-8968, 2019
2372019
The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
AC Faesen, MPA Luna-Vargas, PP Geurink, M Clerici, R Merkx, ...
Chemistry & biology 18 (12), 1550-1561, 2011
2232011
Photoaffinity labeling in activity-based protein profiling
PP Geurink, LM Prely, GA van der Marel, R Bischoff, HS Overkleeft
Activity-based protein profiling, 85-113, 2012
1542012
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne
TET Mevissen, Y Kulathu, MPC Mulder, PP Geurink, SL Maslen, M Gersch, ...
Nature 538 (7625), 402-405, 2016
1462016
The molecular basis for ubiquitin and ubiquitin-like specificities in bacterial effector proteases
JN Pruneda, CH Durkin, PP Geurink, H Ovaa, B Santhanam, DW Holden, ...
Molecular cell 63 (2), 261-276, 2016
1362016
Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit β5t
BI Florea, M Verdoes, N Li, WA van der Linden, PP Geurink, ...
Chemistry & biology 17 (8), 795-801, 2010
1172010
Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis
S Liu, R González-Prieto, M Zhang, PP Geurink, R Kooij, PV Iyengar, ...
Clinical Cancer Research 26 (6), 1460-1473, 2020
1082020
Non-hydrolyzable diubiquitin probes reveal linkage-specific reactivity of deubiquitylating enzymes mediated by S2 pockets
D Flierman, R Ekkebus, PP Geurink, TET Mevissen, MK Hospenthal, ...
Cell chemical biology 23 (4), 472-482, 2016
1072016
Structural basis of the specificity of USP18 toward ISG15
A Basters, PP Geurink, A Röcker, KF Witting, R Tadayon, S Hess, ...
Nature structural & molecular biology 24 (3), 270-278, 2017
1042017
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites
PP Geurink, WA van der Linden, AC Mirabella, N Gallastegui, G de Bruin, ...
Journal of medicinal chemistry 56 (3), 1262-1275, 2013
1032013
A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents
PP Geurink, A Jonker, DS Hameed, H Ovaa
ChemBioChem 13 (2), 293, 2012
1012012
Nature of pharmacophore influences active site specificity of proteasome inhibitors
M Screen, M Britton, SL Downey, M Verdoes, MJ Voges, AEM Blom, ...
Journal of biological chemistry 285 (51), 40125-40134, 2010
742010
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies
KN Swatek, M Aumayr, JN Pruneda, LJ Visser, S Berryman, AF Kueck, ...
Proceedings of the National Academy of Sciences 115 (10), 2371-2376, 2018
652018
A fluorescence polarization activity-based protein profiling assay in the discovery of potent, selective inhibitors for human nonlysosomal glucosylceramidase
D Lahav, B Liu, RJ van den Berg, AMCH van den Nieuwendijk, ...
Journal of the American Chemical Society 139 (40), 14192-14197, 2017
652017
A cleavable linker based on the levulinoyl ester for activity-based protein profiling
PP Geurink, BI Florea, N Li, MD Witte, J Verasdonck, CL Kuo, ...
Angewandte Chemie International Edition 49 (38), 6802-6805, 2010
632010
A cleavable linker based on the levulinoyl ester for activity-based protein profiling
PP Geurink, BI Florea, N Li, MD Witte, J Verasdonck, CL Kuo, ...
Angewandte Chemie International Edition 49 (38), 6802-6805, 2010
632010
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