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Leroy Wheeler
Leroy Wheeler
Principal Scientist II at Novartis Institutes for BioMedical Research
Verified email at novartis.com - Homepage
Title
Cited by
Cited by
Year
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
JR McDole, LW Wheeler, KG McDonald, B Wang, V Konjufca, KA Knoop, ...
Nature 483 (7389), 345-349, 2012
10062012
Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids
KG McDonald, MR Leach, KWM Brooke, C Wang, LW Wheeler, EK Hanly, ...
The American journal of pathology 180 (3), 984-997, 2012
832012
Preclinical evaluation of bispecific adaptor molecule controlled folate receptor CAR-T cell therapy with special focus on pediatric malignancies
YJ Lu, H Chu, LW Wheeler, M Nelson, E Westrick, JF Matthaei, II Cardle, ...
Frontiers in oncology 9, 151, 2019
512019
Cyclin A-CDK activity during G1 phase impairs MCM chromatin loading and inhibits DNA synthesis in mammalian cells
LW Wheeler, NH Lents, JJ Baldassare
Cell Cycle 7 (14), 2179-2188, 2008
512008
Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development
C Wang, EK Hanly, LW Wheeler, M Kaur, KG McDonald, RD Newberry
Inflammatory bowel diseases 16 (10), 1751-1762, 2010
412010
Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis
Y Lu, KN Wollak, VA Cross, E Westrick, LW Wheeler, TW Stinnette, ...
Clinical Immunology 150 (1), 64-77, 2014
252014
Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D
NH Lents, LW Wheeler, JJ Baldassare, BD Dynlacht
Cell Cycle 7 (11), 1580-1586, 2008
182008
CCR6 promotes steady‐state mononuclear phagocyte association with the intestinal epithelium, imprinting and immune surveillance
KG McDonald, LW Wheeler, JR McDole, S Joerger, JK Gustafsson, ...
Immunology 152 (4), 613-627, 2017
152017
Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes
YJ Lu, LW Wheeler, H Chu, PJ Kleindl, M Pugh, F You, S Rao, G Garcia, ...
Cell Reports Medicine 2 (10), 2021
122021
The rapid activation of N-Ras by α-thrombin in fibroblasts is mediated by the specific G-protein Gαi2–Gβ1–Gγ5 and occurs in lipid rafts
NH Lents, V Irintcheva, R Goel, LW Wheeler, JJ Baldassare
Cellular signalling 21 (6), 1007-1014, 2009
112009
Compositions and methods for CAR T cell therapy
PS Low, CHU Haiyan, YG Lee, CP Leamon, IILW Wheeler
US Patent 11,759,480, 2023
32023
Adaptor controlled CAR-T cell immunotherapy for treatment of folate receptor-alpha/beta positive solid and liquid tumors
YJ Lu, H Chu, LW Wheeler, M Nelson, EM Westrick, MR Vetzel, PJ Klein, ...
Cancer Research 78 (13), 2018
22018
Combinatorial strategies of folate receptor-targeted chemotherapy guided by improved understanding of tumor microenvironment and immunomodulation
Y Lu, LW Wheeler, VA Cross, EM Westrick, AM Lloyd, TP Johnson, ...
Cancer Research 77 (13_Supplement), 4574-4574, 2017
22017
Functional folate receptor cells within synovium and fluid as therapeutic targets for osteoarthritis
MF Hsueh, Y Lu, L Wheeler, SS Wellman, MP Bolognesi, VB Kraus
Osteoarthritis and Cartilage 25, S42-S43, 2017
22017
Regulation of CAR-T cell therapy in real time using bispecific small molecule adaptors and monospecific competitors
H Chu, Y Lu, YG Lee, L Wheeler, M Nelson, E Westrick, M Vetzel, PJ Klein, ...
Cancer Research 78 (13_Supplement), 2546-2546, 2018
12018
Specificity of PSMA-617 radiotherapy for prostate cancer
JA Reddy, M Nelson, LC Xu, E Westrick, M Vetzel, L Wheeler, A Felten, ...
Cancer Research 78 (13_Supplement), 852-852, 2018
12018
Abstract LB-109: Adaptor controlled CAR-T cell immunotherapy for treatment of folate receptor-alpha/beta positive solid and liquid tumors
YJ Lu, H Chu, LW Wheeler, M Nelson, EM Westrick, MR Vetzel, PJ Klein, ...
Cancer Research 78 (13_Supplement), LB-109-LB-109, 2018
12018
Combination therapy of folate-targeted chemotherapeutics with anti-PD-1 antibody against folate receptor-positive tumors in immunocompetent murine models
YJ Lu, LW Wheeler, V Cross, E Westrick, A Lloyd, CP Leamon
Cancer Research 76 (14_Supplement), 262-262, 2016
12016
CCR6 expression by small intestine lamina propria dendritic cells is critical for surveillance of the luminal contents at the villous epithelial surface (CCR5P. 251)
K McDonald, L Wheeler, J McDole, M Miller, R Newberry
The Journal of Immunology 192 (1_Supplement), 181.5-181.5, 2014
12014
Methods for using car t cells
PS Low, MC Jensen, J Matthaei, H Chu, YJ Lu, CP Leamon, LWI Wheeler
2020
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