| Tumor necrosis factorα modulates matrix production and catabolism in nucleus pulposus tissue CA Séguin, RM Pilliar, PJ Roughley, RA Kandel Spine 30 (17), 1940-1948, 2005 | 402 | 2005 |
| Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency A Hotta, AYL Cheung, N Farra, K Vijayaragavan, CA Séguin, JS Draper, ... Nature methods 6 (5), 370-376, 2009 | 378 | 2009 |
| Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells CA Séguin, JS Draper, A Nagy, J Rossant Cell stem cell 3 (2), 182-195, 2008 | 260 | 2008 |
| Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development MR McCann, OJ Tamplin, J Rossant, CA Séguin Disease models & mechanisms 5 (1), 73-82, 2012 | 233 | 2012 |
| TNFα suppresses link protein and type II collagen expression in chondrocytes: role of MEK1/2 and NF‐κB signaling pathways CA Séguin, SM Bernier Journal of cellular physiology 197 (3), 356-369, 2003 | 195 | 2003 |
| Differential regulation of matrix degrading enzymes in a TNFα-induced model of nucleus pulposus tissue degeneration CA Séguin, M Bojarski, RM Pilliar, PJ Roughley, RA Kandel Matrix biology 25 (7), 409-418, 2006 | 160 | 2006 |
| Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrate CA Séguin, MD Grynpas, RM Pilliar, SD Waldman, RA Kandel Spine 29 (12), 1299-1306, 2004 | 158 | 2004 |
| Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, ... Bone Research 5 (1), 1-14, 2017 | 124 | 2017 |
| TNF-α induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration CA Séguin, RM Pilliar, JA Madri, RA Kandel Spine 33 (4), 356-365, 2008 | 122 | 2008 |
| Geometric control of cardiomyogenic induction in human pluripotent stem cells CL Bauwens, H Song, N Thavandiran, M Ungrin, S Massé, ... Tissue Engineering Part A 17 (15-16), 1901-1909, 2011 | 118 | 2011 |
| Notochord cells in intervertebral disc development and degeneration MR McCann, CA Séguin Journal of developmental biology 4 (1), 3, 2016 | 115 | 2016 |
| Formation of a nucleus pulposus-cartilage endplate construct in vitro DJ Hamilton, CA Séguin, J Wang, RM Pilliar, RA Kandel Biomaterials 27 (3), 397-405, 2006 | 103 | 2006 |
| Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans S Warraich, DBJ Bone, D Quinonez, H Ii, DS Choi, DW Holdsworth, ... Journal of Bone and Mineral Research 28 (5), 1135-1149, 2013 | 97 | 2013 |
| Innervation of the human intervertebral disc: a scoping review AMR Groh, DE Fournier, MC Battié, CA Séguin Pain Medicine 22 (6), 1281-1304, 2021 | 94 | 2021 |
| BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm A Paca, CA Séguin, M Clements, M Ryczko, J Rossant, TA Rodriguez, ... Developmental biology 361 (1), 90-102, 2012 | 87 | 2012 |
| Vascularization of the human intervertebral disc: a scoping review DE Fournier, PK Kiser, JK Shoemaker, MC Battié, CA Séguin JOR spine 3 (4), e1123, 2020 | 86 | 2020 |
| Histological and reference system for the analysis of mouse intervertebral disc V Tam, WCW Chan, VYL Leung, KSE Cheah, KMC Cheung, D Sakai, ... Journal of Orthopaedic Research® 36 (1), 233-243, 2018 | 86 | 2018 |
| Impaired intervertebral disc development and premature disc degeneration in mice with notochord‐specific deletion of CCN2 J Bedore, W Sha, MR McCann, S Liu, A Leask, CA Séguin Arthritis & Rheumatism 65 (10), 2634-2644, 2013 | 74 | 2013 |
| Repeated exposure to high‐frequency low‐amplitude vibration induces degeneration of murine intervertebral discs and knee joints MR McCann, P Patel, MA Pest, A Ratneswaran, G Lalli, KL Beaucage, ... Arthritis & Rheumatology 67 (8), 2164-2175, 2015 | 70 | 2015 |
| Targeting the extracellular matrix: matricellular proteins regulate cell–extracellular matrix communication within distinct niches of the intervertebral disc J Bedore, A Leask, CA Séguin Matrix Biology 37, 124-130, 2014 | 69 | 2014 |
