An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production Y Tian, B Bassit, D Chau, YM Li Nature structural & molecular biology 17 (2), 151-158, 2010 | 118 | 2010 |
Modulation of γ-secretase specificity using small molecule allosteric inhibitors CC Shelton, L Zhu, D Chau, L Yang, R Wang, H Djaballah, H Zheng, ... Proceedings of the National Academy of Sciences 106 (48), 20228-20233, 2009 | 100 | 2009 |
Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1 CJ Crump, BA Fish, SV Castro, DM Chau, N Gertsik, K Ahn, C Stiff, ... ACS chemical neuroscience 2 (12), 705-710, 2011 | 76 | 2011 |
Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase DM Chau, CJ Crump, JC Villa, DA Scheinberg, YM Li Journal of Biological Chemistry 287 (21), 17288-17296, 2012 | 73 | 2012 |
Development of clickable active site-directed photoaffinity probes for γ-secretase CJ Crump, CW am Ende, TE Ballard, N Pozdnyakov, M Pettersson, ... Bioorganic & medicinal chemistry letters 22 (8), 2997-3000, 2012 | 37 | 2012 |
A novel high throughput 1536-well Notch1 γ-secretase AlphaLISA assay DM Chau, D Shum, C Radu, B Bhinder, D Gin, ML Gilchrist, H Djaballah, ... Combinatorial chemistry & high throughput screening 16 (6), 415-424, 2013 | 21 | 2013 |
Non-natural and photo-reactive amino acids as biochemical probes of immune function M Gomez-Nunez, KJ Haro, T Dao, D Chau, A Won, S Escobar-Alvarez, ... PLoS One 3 (12), e3938, 2008 | 20 | 2008 |
γ-secretase inhibitors and modulators induce distinct conformational changes in the active sites of γ-secretase and signal peptide peptidase N Gertsik, DM Chau, YM Li ACS chemical biology 10 (8), 1925-1931, 2015 | 18 | 2015 |
Malaysian educational module on responsible conduct of research DM Chau, LC Chai, A Veerakumarasivam Kuala Lumpur (Malaysia): Academy of Sciences Malaysia, 2018 | 11 | 2018 |
Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome HH Yusof, HC Lee, EA Seth, X Wu, CA Hewitt, HS Scott, PS Cheah, YM Li, ... Journal of Molecular Neuroscience 67, 632-642, 2019 | 5 | 2019 |
Photo-Reactive and Non-Natural Amino Acid Epitopes of Human WT1 Enhance Immunogenicity and Allow Kinetic Study of Antigen Processing. KJ Haro, M Gomez-Nunez, T Dao, D Chau, A Won, S Escobar-Alvarez, ... Blood, The Journal of the American Society of Hematology 110 (11), 2311-2311, 2007 | 4 | 2007 |
A comprehensive review of cystic fibrosis in Africa and Asia KA Bobbo, U Ahmad, DM Chau, N Nordin, S Abdullah Saudi journal of biological sciences, 103685, 2023 | 2 | 2023 |
Make research-integrity education fun and relevant D Chau Nature 587 (7832), 9-9, 2020 | 2 | 2020 |
Mainstreaming responsible conduct of research education in Malaysia DM Chau, LC Chai, MS Cheema, A Veerakumarasivam Forensic Sciences Research 6 (4), 338-340, 2021 | 1 | 2021 |
Integrating active learning and content localisation in the delivery of responsible conduct of research education in Malaysia LC Chai, DM Chau, A Veerakumarasivam HIGHER EDUCATION AS AN ENTERPRISE–EMBEDDING THE QUALITY ASSURANCE CULTURE, 13, 2021 | 1 | 2021 |
Functional Transcriptome Analysis of Bladder Cancer Cell Lines Persistently Infected with Oncolytic Newcastle Disease Virus U Ahmad, A Thirumorthy, DM Chau, SL Chia, K Yusoff, S Abdullah, ... bioRxiv, 2020.12. 14.422610, 2020 | 1 | 2020 |
Methods and compositions for gamma-secretase assay YM Li, DM Chau, JC Villa, C Crump US Patent 9,632,088, 2017 | 1 | 2017 |
Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression FW Chin, H Hussin, DM Chau, TA Ong, R Yunus, AH Abdul Razack, ... Diagnostics 13 (16), 2636, 2023 | | 2023 |
Analysis of PPI networks of transcriptomic expression identifies hub genes associated with Newcastle disease virus persistent infection in bladder cancer U Ahmad, S Abdullah, DM Chau, SL Chia, K Yusoff, SC Chan, TA Ong, ... Scientific Reports 13 (1), 7323, 2023 | | 2023 |
EMBEDDING RESEARCH INTEGRITY TO ENSURE QUALITY OF HIGHER EDUCATION IN MALAYSIA DM Chau, LC Chai, A Veerakumarasivam HIGHER EDUCATION AS AN ENTERPRISE–EMBEDDING THE QUALITY ASSURANCE CULTURE, 81, 2021 | | 2021 |