Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression LS Qi, MH Larson, LA Gilbert, JA Doudna, JS Weissman, AP Arkin, ... Cell 152 (5), 1173-1183, 2013 | 5962 | 2013 |
Global analysis of protein localization in budding yeast WK Huh, JV Falvo, LC Gerke, AS Carroll, RW Howson, JS Weissman, ... Nature 425 (6959), 686-691, 2003 | 5207 | 2003 |
Mammalian microRNAs predominantly act to decrease target mRNA levels H Guo, NT Ingolia, JS Weissman, DP Bartel Nature 466 (7308), 835-840, 2010 | 4729 | 2010 |
Global analysis of protein expression in yeast S Ghaemmaghami, WK Huh, K Bower, RW Howson, A Belle, N Dephoure, ... Nature 425 (6959), 737-741, 2003 | 4685 | 2003 |
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes LA Gilbert, MH Larson, L Morsut, Z Liu, GA Brar, SE Torres, ... Cell 154 (2), 442-451, 2013 | 4461 | 2013 |
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling NT Ingolia, S Ghaemmaghami, JRS Newman, JS Weissman science 324 (5924), 218-223, 2009 | 4199 | 2009 |
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae NJ Krogan, G Cagney, H Yu, G Zhong, X Guo, A Ignatchenko, J Li, S Pu, ... Nature 440 (7084), 637-643, 2006 | 3494 | 2006 |
CRISPR/Cas, the immune system of bacteria and archaea P Horvath, R Barrangou Science 327 (5962), 167-170, 2010 | 3392 | 2010 |
Genome-scale CRISPR-mediated control of gene repression and activation LA Gilbert, MA Horlbeck, B Adamson, JE Villalta, Y Chen, EH Whitehead, ... Cell 159 (3), 647-661, 2014 | 2965 | 2014 |
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation KJ Travers, CK Patil, L Wodicka, DJ Lockhart, JS Weissman, P Walter Cell 101 (3), 249-258, 2000 | 2391 | 2000 |
Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes NT Ingolia, LF Lareau, JS Weissman Cell 147 (4), 789-802, 2011 | 2369 | 2011 |
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system B Chen, LA Gilbert, BA Cimini, J Schnitzbauer, W Zhang, GW Li, J Park, ... Cell 155 (7), 1479-1491, 2013 | 2290 | 2013 |
The human cell atlas A Regev, SA Teichmann, ES Lander, I Amit, C Benoist, E Birney, ... elife 6, e27041, 2017 | 2211 | 2017 |
Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States RS Lanciotti, JT Roehrig, V Deubel, J Smith, M Parker, K Steele, B Crise, ... Science 286 (5448), 2333-2337, 1999 | 1980 | 1999 |
Molecular chaperones and protein quality control B Bukau, J Weissman, A Horwich Cell 125 (3), 443-451, 2006 | 1919 | 2006 |
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise JRS Newman, S Ghaemmaghami, J Ihmels, DK Breslow, M Noble, ... Nature 441 (7095), 840-846, 2006 | 1763 | 2006 |
A protein-tagging system for signal amplification in gene expression and fluorescence imaging ME Tanenbaum, LA Gilbert, LS Qi, JS Weissman, RD Vale Cell 159 (3), 635-646, 2014 | 1696 | 2014 |
Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens A Dixit, O Parnas, B Li, J Chen, CP Fulco, L Jerby-Arnon, ND Marjanovic, ... cell 167 (7), 1853-1866. e17, 2016 | 1553 | 2016 |
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response J Hollien, JS Weissman Science 313 (5783), 104-107, 2006 | 1532 | 2006 |
CRISPR interference (CRISPRi) for sequence-specific control of gene expression MH Larson, LA Gilbert, X Wang, WA Lim, JS Weissman, LS Qi Nature protocols 8 (11), 2180-2196, 2013 | 1501 | 2013 |