Proteome-wide covalent ligand discovery in native biological systems KM Backus, BE Correia, KM Lum, S Forli, BD Horning, GE González-Páez, ... Nature 534 (7608), 570-574, 2016 | 799 | 2016 |
Macromolecular modeling and design in Rosetta: recent methods and frameworks JK Leman, BD Weitzner, SM Lewis, J Adolf-Bryfogle, N Alam, RF Alford, ... Nature methods 17 (7), 665-680, 2020 | 690 | 2020 |
Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning P Gainza, F Sverrisson, F Monti, E Rodola, D Boscaini, MM Bronstein, ... Nature Methods 17 (2), 184-192, 2020 | 663 | 2020 |
Proof of principle for epitope-focused vaccine design BE Correia, JT Bates, RJ Loomis, G Baneyx, C Carrico, JG Jardine, ... Nature 507 (7491), 201-206, 2014 | 590 | 2014 |
Global profiling of lysine reactivity and ligandability in the human proteome SM Hacker, KM Backus, MR Lazear, S Forli, BE Correia, BF Cravatt Nature chemistry 9 (12), 1181-1190, 2017 | 417 | 2017 |
Ligand and target discovery by fragment-based screening in human cells CG Parker, A Galmozzi, Y Wang, BE Correia, K Sasaki, CM Joslyn, ... Cell 168 (3), 527-541. e29, 2017 | 408 | 2017 |
Scaffolding protein functional sites using deep learning J Wang, S Lisanza, D Juergens, D Tischer, JL Watson, KM Castro, ... Science 377 (6604), 387-394, 2022 | 314 | 2022 |
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant G Bouvignies, P Vallurupalli, DF Hansen, BE Correia, O Lange, A Bah, ... Nature 477 (7362), 111-114, 2011 | 312 | 2011 |
Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope BE Correia, YEA Ban, MA Holmes, H Xu, K Ellingson, Z Kraft, C Carrico, ... Structure 18 (9), 1116-1126, 2010 | 256 | 2010 |
Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold ML Azoitei, BE Correia, YEA Ban, C Carrico, O Kalyuzhniy, L Chen, ... Science 334 (6054), 373-376, 2011 | 248 | 2011 |
A global map of lipid-binding proteins and their ligandability in cells MJ Niphakis, KM Lum, AB Cognetta, BE Correia, TA Ichu, J Olucha, ... Cell 161 (7), 1668-1680, 2015 | 227 | 2015 |
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning DM Mason, S Friedensohn, CR Weber, C Jordi, B Wagner, SM Meng, ... Nature Biomedical Engineering 5 (6), 600-612, 2021 | 223 | 2021 |
Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9 F Bubeck, MD Hoffmann, Z Harteveld, S Aschenbrenner, A Bietz, ... Nature methods 15 (11), 924-927, 2018 | 212 | 2018 |
De novo protein design enables the precise induction of RSV-neutralizing antibodies F Sesterhenn, C Yang, J Bonet, JT Cramer, X Wen, Y Wang, CI Chiang, ... Science 368 (6492), eaay5051, 2020 | 170 | 2020 |
A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells E Procko, GY Berguig, BW Shen, Y Song, S Frayo, AJ Convertine, ... Cell 157 (7), 1644-1656, 2014 | 149 | 2014 |
Fast end-to-end learning on protein surfaces F Sverrisson, J Feydy, BE Correia, MM Bronstein Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern …, 2021 | 146 | 2021 |
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy G Giordano-Attianese, P Gainza, E Gray-Gaillard, E Cribioli, S Shui, S Kim, ... Nature biotechnology 38 (4), 426-432, 2020 | 138 | 2020 |
Antibodies to combat viral infections: development strategies and progress G Pantaleo, B Correia, C Fenwick, VS Joo, L Perez Nature Reviews Drug Discovery 21 (9), 676-696, 2022 | 136 | 2022 |
Equivariant 3D-conditional diffusion model for molecular linker design I Igashov, H Stärk, C Vignac, A Schneuing, VG Satorras, P Frossard, ... Nature Machine Intelligence, 1-11, 2024 | 131 | 2024 |
De novo design of protein interactions with learned surface fingerprints P Gainza, S Wehrle, A Van Hall-Beauvais, A Marchand, A Scheck, ... Nature 617 (7959), 176-184, 2023 | 126 | 2023 |