| mRNA-Seq whole-transcriptome analysis of a single cell F Tang, C Barbacioru, Y Wang, E Nordman, C Lee, N Xu, X Wang, ... Nature methods 6 (5), 377-382, 2009 | 4084 | 2009 |
| Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children A Drilon, TW Laetsch, S Kummar, SG DuBois, UN Lassen, GD Demetri, ... New England Journal of Medicine 378 (8), 731-739, 2018 | 2723 | 2018 |
| The developmental transcriptome of Drosophila melanogaster BR Graveley, AN Brooks, JW Carlson, MO Duff, JM Landolin, L Yang, ... Nature 471 (7339), 473-479, 2011 | 1725 | 2011 |
| Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution LJ Holt, BB Tuch, J Villén, AD Johnson, SP Gygi, DO Morgan Science 325 (5948), 1682-1686, 2009 | 1061 | 2009 |
| A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans CJ Nobile, EP Fox, JE Nett, TR Sorrells, QM Mitrovich, AD Hernday, ... Cell 148 (1), 126-138, 2012 | 789 | 2012 |
| Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study TW Laetsch, SG DuBois, L Mascarenhas, B Turpin, N Federman, ... The Lancet Oncology 19 (5), 705-714, 2018 | 546 | 2018 |
| An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101 RC Doebele, LE Davis, A Vaishnavi, AT Le, A Estrada-Bernal, S Keysar, ... Cancer discovery 5 (10), 1049-1057, 2015 | 420* | 2015 |
| A next-generation TRK kinase inhibitor overcomes acquired resistance to prior TRK kinase inhibition in patients with TRK fusion–positive solid tumors A Drilon, R Nagasubramanian, JF Blake, N Ku, BB Tuch, K Ebata, S Smith, ... Cancer discovery 7 (9), 963-972, 2017 | 414 | 2017 |
| Selective RET kinase inhibition for patients with RET-altered cancers V Subbiah, V Velcheti, BB Tuch, K Ebata, NL Busaidy, ME Cabanillas, ... Annals of Oncology 29 (8), 1869-1876, 2018 | 395 | 2018 |
| An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis C Chen, K Pande, SD French, BB Tuch, SM Noble Cell host & microbe 10 (2), 118-135, 2011 | 356 | 2011 |
| Interlocking transcriptional feedback loops control white-opaque switching in Candida albicans RE Zordan, MG Miller, DJ Galgoczy, BB Tuch, AD Johnson PLoS biology 5 (10), e256, 2007 | 334 | 2007 |
| Evolution of alternative transcriptional circuits with identical logic AE Tsong, BB Tuch, H Li, AD Johnson Nature 443 (7110), 415-420, 2006 | 307 | 2006 |
| The evolution of combinatorial gene regulation in fungi BB Tuch, DJ Galgoczy, AD Hernday, H Li, AD Johnson PLoS Biology 6 (2), e38, 2008 | 297 | 2008 |
| RET solvent front mutations mediate acquired resistance to selective RET inhibition in RET-driven malignancies BJ Solomon, L Tan, JJ Lin, SQ Wong, S Hollizeck, K Ebata, BB Tuch, ... Journal of Thoracic Oncology 15 (4), 541-549, 2020 | 251 | 2020 |
| Resistance to TRK inhibition mediated by convergent MAPK pathway activation E Cocco, AM Schram, A Kulick, S Misale, HH Won, R Yaeger, P Razavi, ... Nature medicine 25 (9), 1422-1427, 2019 | 200 | 2019 |
| Evolution of eukaryotic transcription circuits BB Tuch, H Li, AD Johnson Science 319 (5871), 1797-1799, 2008 | 183 | 2008 |
| Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations BB Tuch, RR Laborde, X Xu, J Gu, CB Chung, CK Monighetti, SJ Stanley, ... PloS one 5 (2), e9317, 2010 | 172 | 2010 |
| The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation BB Tuch, QM Mitrovich, OR Homann, AD Hernday, CK Monighetti, ... PLoS genetics 6 (8), e1001070, 2010 | 171 | 2010 |
| Deterministic and stochastic allele specific gene expression in single mouse blastomeres F Tang, C Barbacioru, E Nordman, S Bao, C Lee, X Wang, BB Tuch, ... PloS one 6 (6), e21208, 2011 | 159 | 2011 |
| Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study DS Hong, TM Bauer, JJ Lee, A Dowlati, MS Brose, AF Farago, M Taylor, ... Annals of Oncology 30 (2), 325-331, 2019 | 156 | 2019 |
Catalin BarbacioruDirector, Bioinformatics at Guardant HealthVerified email at guardanthealth.com
