NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights SM Gough, CI Slape, PD Aplan Blood, The Journal of the American Society of Hematology 118 (24), 6247-6257, 2011 | 354 | 2011 |
NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia YW Lin, C Slape, Z Zhang, PD Aplan Blood 106 (1), 287-295, 2005 | 262 | 2005 |
The role of NUP98 gene fusions in hematologic malignancy C Slape, PD Aplan Leukemia & lymphoma 45 (7), 1341-1350, 2004 | 130 | 2004 |
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model S Greenblatt, L Li, C Slape, B Nguyen, R Novak, A Duffield, D Huso, ... Blood, The Journal of the American Society of Hematology 119 (12), 2883-2894, 2012 | 97 | 2012 |
Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation C Slape, H Hartung, YW Lin, J Bies, L Wolff, PD Aplan Cancer research 67 (11), 5148-5155, 2007 | 82 | 2007 |
EphA3 biology and cancer PW Janes, CI Slape, RH Farnsworth, L Atapattu, AM Scott, ME Vail Growth factors 32 (6), 176-189, 2014 | 80 | 2014 |
Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl C Slape, LY Liu, S Beachy, PD Aplan Blood, The Journal of the American Society of Hematology 112 (5), 2017-2019, 2008 | 77 | 2008 |
Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome CI Slape, J Saw, JBM Jowett, PD Aplan, A Strasser, SM Jane, DJ Curtis Blood, The Journal of the American Society of Hematology 120 (12), 2475-2483, 2012 | 50 | 2012 |
Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell YJ Chung, CW Choi, C Slape, T Fry, PD Aplan Proceedings of the National Academy of Sciences 105 (37), 14088-14093, 2008 | 49 | 2008 |
NUP98-HOX translocations lead to myelodysplastic syndrome in mice and men C Slape, YW Lin, H Hartung, Z Zhang, L Wolff, PD Aplan Journal of the National Cancer Institute Monographs 2008 (39), 64-68, 2008 | 44 | 2008 |
OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1 YW Lin, R Deveney, M Barbara, NN Iscove, SD Nimer, C Slape, PD Aplan Cancer Research 65 (16), 7151-7158, 2005 | 35 | 2005 |
Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes RL Novak, DP Harper, D Caudell, C Slape, SH Beachy, PD Aplan Experimental hematology 40 (12), 1016-1027, 2012 | 33 | 2012 |
A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement CW Choi, YJ Chung, C Slape, PD Aplan The Journal of Immunology 183 (10), 6227-6235, 2009 | 33 | 2009 |
Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome CW Choi, YJ Chung, C Slape, PD Aplan Haematologica 93 (9), 1394, 2008 | 29 | 2008 |
Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice D Caudell, DP Harper, RL Novak, RM Pierce, C Slape, L Wolff, PD Aplan Blood, The Journal of the American Society of Hematology 115 (6), 1194-1203, 2010 | 28 | 2010 |
PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia AA Guirguis, CI Slape, LM Failla, J Saw, CS Tremblay, DR Powell, ... Cell Death & Differentiation 23 (6), 1049-1059, 2016 | 18 | 2016 |
The fusion partner specifies the oncogenic potential of NUP98 fusion proteins J Saw, DJ Curtis, DJ Hussey, A Dobrovic, PD Aplan, CI Slape Leukemia research 37 (12), 1668-1673, 2013 | 18 | 2013 |
Mouse embryonic stem cells that express a NUP98–HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL C Slape, YJ Chung, PD Soloway, L Tessarollo, PD Aplan Leukemia 21 (6), 1239-1248, 2007 | 15 | 2007 |
The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1 BJ Shields, CI Slape, N Vo, JT Jackson, A Pliego-Zamora, H Ranasinghe, ... Leukemia 33 (8), 1868-1880, 2019 | 13 | 2019 |
Cre-/IoxP-Mediated Recombination between the SIL and SCL Genes Leads to a Block in T-Cell Development at the CD4-CD8-to CD4+ CD8+ Transition Y Cheng, Z Zhang, C Slape, PD Aplan Neoplasia 9 (4), 315-321, 2007 | 11 | 2007 |