Adam J. Engler
Adam J. Engler
Professor and Chair, Chien-Lay Dept. of Bioengineering, UC San Diego
Verified email at - Homepage
Cited by
Cited by
Matrix elasticity directs stem cell lineage specification
AJ Engler, S Sen, HL Sweeney, DE Discher
Cell 126 (4), 677-689, 2006
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments
AJ Engler, MA Griffin, S Sen, CG Bonnemann, HL Sweeney, DE Discher
The Journal of cell biology 166 (6), 877-887, 2004
Substrate compliance versus ligand density in cell on gel responses
A Engler, L Bacakova, C Newman, A Hategan, M Griffin, D Discher
Biophysical journal 86 (1), 617-628, 2004
Stem cell fate dictated solely by altered nanotube dimension
S Oh, KS Brammer, YSJ Li, D Teng, AJ Engler, S Chien, S Jin
Proceedings of the National Academy of Sciences 106 (7), 2130-2135, 2009
Preparation of hydrogel substrates with tunable mechanical properties
JR Tse, AJ Engler
Current protocols in cell biology 47 (1), 10.16. 1-10.16. 16, 2010
Interplay of matrix stiffness and protein tethering in stem cell differentiation
JH Wen, LG Vincent, A Fuhrmann, YS Choi, KC Hribar, H Taylor-Weiner, ...
Nature materials 13 (10), 979-987, 2014
Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating
AJ Engler, C Carag-Krieger, CP Johnson, M Raab, HY Tang, ...
Journal of cell science 121 (22), 3794-3802, 2008
Materials as stem cell regulators
WL Murphy, TC McDevitt, AJ Engler
Nature materials 13 (6), 547-557, 2014
Intrinsic extracellular matrix properties regulate stem cell differentiation
GC Reilly, AJ Engler
Journal of biomechanics 43 (1), 55-62, 2010
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance
MF Berry, AJ Engler, YJ Woo, TJ Pirolli, LT Bish, V Jayasankar, KJ Morine, ...
American Journal of Physiology-Heart and Circulatory Physiology 290 (6 …, 2006
Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
SC Wei, L Fattet, JH Tsai, Y Guo, VH Pai, HE Majeski, AC Chen, RL Sah, ...
Nature cell biology 17 (5), 678-688, 2015
Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate
JR Tse, AJ Engler
PloS one 6 (1), e15978, 2011
Cell responses to the mechanochemical microenvironment—implications for regenerative medicine and drug delivery
F Rehfeldt, AJ Engler, A Eckhardt, F Ahmed, DE Discher
Advanced drug delivery reviews 59 (13), 1329-1339, 2007
Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels
WJ Hadden, JL Young, AW Holle, ML McFetridge, DY Kim, P Wijesinghe, ...
Proceedings of the National Academy of Sciences 114 (22), 5647-5652, 2017
Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: correlations between substrate stiffness and cell adhesion
AJ Engler, L Richert, JY Wong, C Picart, DE Discher
Surface science 570 (1-2), 142-154, 2004
Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro
JL Young, AJ Engler
Biomaterials 32 (4), 1002-1009, 2011
Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures
KN Dahl, AJ Engler, JD Pajerowski, DE Discher
Biophysical journal 89 (4), 2855-2864, 2005
Recent advances in extrusion‐based 3D printing for biomedical applications
JK Placone, AJ Engler
Advanced healthcare materials 7 (8), 1701161, 2018
Photopolymerization in microfluidic gradient generators: microscale control of substrate compliance to manipulate cell response
N Zaari, P Rajagopalan, SK Kim, AJ Engler, JY Wong
Advanced materials 16 (23‐24), 2133-2137, 2004
RAP2 mediates mechanoresponses of the Hippo pathway
Z Meng, Y Qiu, KC Lin, A Kumar, JK Placone, C Fang, KC Wang, S Lu, ...
Nature 560 (7720), 655-660, 2018
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