Masoud Vedadi
Masoud Vedadi
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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
FH Niesen, H Berglund, M Vedadi
Nature protocols 2 (9), 2212-2221, 2007
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ...
Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
J Zhu, MA Sammons, G Donahue, Z Dou, M Vedadi, M Getlik, ...
Nature 525 (7568), 206-211, 2015
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity
A Schuetz, J Min, A Allali-Hassani, M Schapira, M Shuen, P Loppnau, ...
Journal of Biological Chemistry 283 (17), 11355-11363, 2008
Recognition and specificity determinants of the human cbx chromodomains
L Kaustov, H Ouyang, M Amaya, A Lemak, N Nady, S Duan, GA Wasney, ...
Journal of Biological Chemistry 286 (1), 521-529, 2011
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms
M Vedadi, J Lew, J Artz, M Amani, Y Zhao, A Dong, GA Wasney, M Gao, ...
Molecular and biochemical parasitology 151 (1), 100-110, 2007
In situ proteolysis for protein crystallization and structure determination
A Dong, X Xu, AM Edwards
Nature methods 4 (12), 1019-1021, 2007
Structural biology of human H3K9 methyltransferases
H Wu, J Min, VV Lunin, T Antoshenko, L Dombrovski, H Zeng, ...
PloS one 5 (1), e8570, 2010
A strategy for modulation of enzymes in the ubiquitin system
A Ernst, G Avvakumov, J Tong, Y Fan, Y Zhao, P Alberts, A Persaud, ...
Science 339 (6119), 590-595, 2013
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
A Schuetz, J Min, T Antoshenko, CL Wang, A Allali-Hassani, A Dong, ...
Structure 15 (3), 377-389, 2007
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ...
Nature communications 3 (1), 1-12, 2012
Structural and chemical profiling of the human cytosolic sulfotransferases
A Allali-Hassani, PW Pan, L Dombrovski, R Najmanovich, W Tempel, ...
PLoS biology 5 (5), e97, 2007
Protein production: feeding the crystallographers and NMR spectroscopists
AM Edwards, CH Arrowsmith, D Christendat, A Dharamsi, JD Friesen, ...
nature structural biology 7 (11), 970-972, 2000
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ...
Journal of medicinal chemistry 52 (24), 7950-7953, 2009
Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium
AK Wernimont, JD Artz, P Finerty, YH Lin, M Amani, A Allali-Hassani, ...
Nature structural & molecular biology 17 (5), 596-601, 2010
L3MBTL1 recognition of mono-and dimethylated histones
J Min, A Allali-Hassani, N Nady, C Qi, H Ouyang, Y Liu, F MacKenzie, ...
Nature structural & molecular biology 14 (12), 1229-1230, 2007
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
B Xu, DM On, A Ma, T Parton, KD Konze, SG Pattenden, DF Allison, L Cai, ...
Blood, The Journal of the American Society of Hematology 125 (2), 346-357, 2015
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