|Factor XII inhibition reduces thrombus formation in a primate thrombosis model|
A Matafonov, PY Leung, AE Gailani, SL Grach, C Puy, Q Cheng, M Sun, ...
Blood 123 (11), 1739-1746, 2014
|Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity|
J LÓPEZ‐SAGASETA, R Montes, C Puy, N Díez, K Fukudome, J Hermida
Journal of Thrombosis and Haemostasis 5 (9), 1817-1824, 2007
|Factor XII promotes blood coagulation independent of factor XI in the presence of long‐chain polyphosphates|
C Puy, EI Tucker, ZC Wong, D Gailani, SA Smith, SH Choi, JH Morrissey, ...
Journal of Thrombosis and Haemostasis 11 (7), 1341-1352, 2013
|Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo|
LD Healy, C Puy, JA Fernández, A Mitrugno, RS Keshari, NA Taku, ...
Journal of Biological Chemistry, jbc. M116. 768309, 2017
|The hemostatic role of factor XI|
C Puy, RA Rigg, OJT McCarty
Thrombosis research 141, S8-S11, 2016
|Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.|
C Puy, EI Tucker, A Matafonov, Q Cheng, KD Zientek, D Gailani, A Gruber, ...
|Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial|
CU Lorentz, NG Verbout, M Wallisch, MW Hagen, JJ Shatzel, SR Olson, ...
Arteriosclerosis, thrombosis, and vascular biology, ATVBAHA. 118.312328, 2019
|The Safety and Efficacy of Novel Agents Targeting Factors XI and XII in Early Phase Human Trials|
EP DeLoughery, SR Olson, C Puy, OJT McCarty, JJ Shatzel
Seminars in Thrombosis and Hemostasis, 2019
|Inhibition of contact-mediated activation of factor XI protects baboons against S aureus–induced organ damage and death|
R Silasi, RS Keshari, C Lupu, WJ Van Rensburg, H Chaaban, G Regmi, ...
Blood advances 3 (4), 658-669, 2019
|Is EPCR a multi-ligand receptor? Pros and cons|
R Montes, C Puy, E Molina, J Hermida
Thrombosis and haemostasis 107 (5), 815, 2012
|Blocking endothelial protein C receptor (EPCR) accelerates thrombus development in vivo|
MN Centelles, C Puy, J Lopez-Sagaseta, K Fukudome, R Montes, ...
|Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen|
I Ivanov, M Sun, SK Dickeson, C Puy, OJT McCarty, A Gruber, ...
Thrombosis and Haemostasis, 2017
|Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo|
J Zilberman-Rudenko, SE Reitsma, C Puy, RA Rigg, SA Smith, EI Tucker, ...
Arteriosclerosis, Thrombosis, and Vascular Biology 38 (8), 1748-1760, 2018
|Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: Development and utility of an immunofluorescence-based microscopy platform|
LD Healy, C Puy, A Itakura, T Chu, DK Robinson, A Bylund, KG Phillips, ...
Journal of Immunological Methods, 2016
|sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove|
J López-Sagaseta, C Puy, I Tamayo, M Allende, J Cerveró, SE Velasco, ...
Blood 119 (12), 2914-2921, 2012
|Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI|
C Puy, EI Tucker, IS Ivanov, D Gailani, SA Smith, JH Morrissey, A Gruber, ...
PloS one 11 (10), e0165172, 2016
|Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates|
M Wallisch, CU Lorentz, HHS Lakshmanan, J Johnson, MR Carris, C Puy, ...
Research and Practice in Thrombosis and Haemostasis 4 (2), 205-216, 2020
|Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Coagulation Factor XI)|
C Puy, ATP Ngo, J Pang, RS Keshari, MW Hagen, MT Hinds, D Gailani, ...
Arteriosclerosis, Thrombosis, and Vascular Biology, ATVBAHA. 119.312619, 2018
|The endothelial cells downregulate the generation of factor VIIa through EPCR binding|
C Puy, J López‐Sagaseta, J Hermida, R Montes
British journal of haematology 149 (1), 111-117, 2010
|Factor X and factor VII binding to endothelial protein C receptor differs between species|
C Puy, J Hermida, R Montes
Journal of Thrombosis and Haemostasis 9 (6), 1255-1257, 2011