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Ryan K Muir
Ryan K Muir
Septerna, Inc
Verified email at septerna.com
Title
Cited by
Cited by
Year
Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19
K Steuten, H Kim, JC Widen, BM Babin, O Onguka, S Lovell, O Bolgi, ...
ACS infectious diseases 7 (6), 1457-1468, 2021
832021
Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting
D Mavor, K Barlow, S Thompson, BA Barad, AR Bonny, CL Cario, ...
Elife 5, e15802, 2016
782016
Measuring dynamic changes in the labile iron pool in vivo with a reactivity-based probe for positron emission tomography
RK Muir, N Zhao, J Wei, Y Wang, A Moroz, Y Huang, YC Chen, R Sriram, ...
ACS central science 5 (4), 727-736, 2019
372019
cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool
V Camarena, DW Sant, TC Huff, S Mustafi, RK Muir, AT Aron, CJ Chang, ...
Elife 6, e29750, 2017
342017
Ferronostics: measuring tumoral ferrous iron with PET to predict sensitivity to iron-targeted cancer therapies
N Zhao, Y Huang, Y Wang, RK Muir, YC Chen, J Wei, N Hooshdaran, ...
Journal of Nuclear Medicine 62 (7), 949-955, 2021
252021
Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors
H Jiang, RK Muir, RL Gonciarz, AB Olshen, I Yeh, BC Hann, N Zhao, ...
Journal of Experimental Medicine 219 (4), e20210739, 2022
162022
Activity-based diagnostics: recent advances in the development of probes for use with diverse detection modalities
RK Muir, M Guerra, MM Bogyo
ACS Chemical Biology 17 (2), 281-291, 2022
152022
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome
I Deni, BH Stokes, KE Ward, KJ Fairhurst, CFA Pasaje, T Yeo, S Akbar, ...
Cell chemical biology 30 (5), 470-485. e6, 2023
92023
Targeting Mobilization of Ferrous Iron in Pseudomonas aeruginosa Infection with an Iron(II)-Caged LpxC Inhibitor
BR Blank, P Talukder, RK Muir, ER Green, EP Skaar, AR Renslo
ACS infectious diseases 5 (8), 1366-1375, 2019
92019
Oscillatory cAMP signaling rapidly alters H3K4 methylation
TC Huff, V Camarena, DW Sant, Z Wilkes, D Van Booven, AT Aron, ...
Life science alliance 3 (1), 2020
62020
Cinnamomum zeylanicum Blume Essential Oil Inhibits Metastatic Melanoma Cell Proliferation by Triggering an Incomplete Tumour Cell Stress Response
G Cappelli, D Giovannini, L Vilardo, A Basso, I Iannetti, M Massa, ...
International Journal of Molecular Sciences 24 (6), 5698, 2023
42023
Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting. eLife 5
D Mavor, K Barlow, S Thompson, BA Barad, AR Bonny, CL Cario, ...
Article e15802. doi, 2016
42016
Exploiting KRAS-driven ferroaddiction in cancer through ferrous iron-activatable drug conjugates (FeADC)
H Jiang, RK Muir, RL Gonciarz, AB Olshen, I Yeh, BC Hann, N Zhao, ...
bioRxiv, 2020.05. 12.088971, 2020
22020
Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum
JM Bennett, KE Ward, RK Muir, S Kabeche, E Yoo, T Yeo, G Lam, ...
ACS Infectious Diseases 9 (10), 2036-2047, 2023
12023
cAMP signaling regulates DNA demethylation by augmenting the intracellular labile ferrous iron pool
V Camarena, DW Sant, TC Huff, S Mustafi, RK Muir, AR Renslo, P Monje, ...
bioRxiv, 162743, 2017
12017
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets
JM Bennett, SK Narwal, S Kabeche, D Abegg, F Hackett, T Yeo, V Li, ...
bioRxiv, 2024.01. 11.575224, 2024
2024
Trioxolane agents
AR Renslo, BR Blank, RK Muir, MJ Evans, P Talukder
US Patent App. 17/680,825, 2022
2022
Trioxolane agents
AR Renslo, BR Blank, RK Muir, MJ Evans, P Talukder
US Patent 11,072,594, 2021
2021
Novel ferrous iron-dependent prodrug strategy for KRAS-driven pancreatic cancer: The preclinic efficacy and safety test
H Jiang, R Muir, A Renslo, E Collisson
Cancer Research 80 (16_Supplement), 6419-6419, 2020
2020
Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19 (preprint)
K Steuten, H Kim, JC Widen, BM Babin, O Onguka, S Lovell, O Bolgi, ...
2020
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