Iain W. Mcnae
Iain W. Mcnae
Verified email at staffmail.ed.ac.uk
Title
Cited by
Cited by
Year
MeCP2 binding to DNA depends upon hydration at methyl-CpG
KL Ho, IW McNae, L Schmiedeberg, RJ Klose, AP Bird, MD Walkinshaw
Molecular cell 29 (4), 525-531, 2008
2562008
2-Anilino-4-(thiazol-5-yl) pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity
S Wang, C Meades, G Wood, A Osnowski, S Anderson, R Yuill, M Thomas, ...
Journal of medicinal chemistry 47 (7), 1662-1675, 2004
1782004
Gene encoding a deubiquitinating enzyme is mutated in artesunate‐ and chloroquine‐resistant rodent malaria parasites§
P Hunt, A Afonso, A Creasey, R Culleton, ABS Sidhu, J Logan, ...
Molecular microbiology 65 (1), 27-40, 2007
1682007
Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop
SY Wu, I McNae, G Kontopidis, SJ McClue, C McInnes, KJ Stewart, ...
Structure 11 (4), 399-410, 2003
1472003
Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity
R Jorda, L Havlícek, IW McNae, MD Walkinshaw, J Voller, A Sturc, ...
Journal of medicinal chemistry 54 (8), 2980-2993, 2011
812011
Antiproliferative activity of olomoucine II, a novel 2, 6, 9-trisubstituted purine cyclin-dependent kinase inhibitor
V Kryštof, IW McNae, MD Walkinshaw, PM Fischer, P Müller, B Vojtěšek, ...
Cellular and Molecular Life Sciences CMLS 62 (15), 1763-1771, 2005
812005
Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme
TM Hunter, IW McNae, X Liang, J Bella, S Parsons, MD Walkinshaw, ...
Proceedings of the National Academy of Sciences 102 (7), 2288-2292, 2005
802005
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site
HP Morgan, IW McNae, MW Nowicki, W Zhong, PAM Michels, DS Auld, ...
Journal of Biological Chemistry 286 (36), 31232-31240, 2011
752011
Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model
HP Morgan, IW McNae, MW Nowicki, V Hannaert, PAM Michels, ...
Journal of Biological Chemistry 285 (17), 12892-12898, 2010
752010
Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis
MW Nowicki, LB Tulloch, L Worralll, IW McNae, V Hannaert, PAM Michels, ...
Bioorganic & medicinal chemistry 16 (9), 5050-5061, 2008
692008
Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives
CJ Brown, I McNae, PM Fischer, MD Walkinshaw
Journal of molecular biology 372 (1), 7-15, 2007
692007
Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors
S Wang, G Wood, C Meades, G Griffiths, C Midgley, I McNae, C McInnes, ...
Bioorganic & medicinal chemistry letters 14 (16), 4237-4240, 2004
642004
Apparent chemical composition of nine commercial or semi‐commercial whey protein concentrates, isolates and fractions
C Holt, D McPhail, I Nevison, T Nylander, J Otte, RH Ipsen, R Bauer, ...
International journal of food science & technology 34 (5‐6), 543-556, 1999
621999
Configurations of Nickel–cyclam antiviral complexes and protein recognition
TM Hunter, IW McNae, DP Simpson, AM Smith, S Moggach, F White, ...
Chemistry–A European Journal 13 (1), 40-50, 2007
592007
Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design
G Kontopidis, C McInnes, SR Pandalaneni, I McNae, D Gibson, M Mezna, ...
Chemistry & biology 13 (2), 201-211, 2006
562006
A recombinant C121S mutant of bovine β-lactoglobulin is more susceptible to peptic digestion and to denaturation by reducing agents and heating
D Jayat, JC Gaudin, JM Chobert, TV Burova, C Holt, I McNae, L Sawyer, ...
Biochemistry 43 (20), 6312-6321, 2004
562004
Half-sandwich arene ruthenium (II)–enzyme complex
IW McNae, K Fishburne, A Habtemariam, TM Hunter, M Melchart, F Wang, ...
Chemical communications, 1786-1787, 2004
532004
Some physico‐chemical properties of nine commercial or semi‐commercial whey protein concentrates, isolates and fractions
C Holt, D McPhail, T Nylander, J Otte, RH Ipsen, R Bauer, L Řgendal, ...
International journal of food science & technology 34 (5‐6), 587-601, 1999
511999
Bivalent enzyme inhibitors discovered using dynamic covalent chemistry
AJ Clipson, VT Bhat, I McNae, AM Caniard, DJ Campopiano, MF Greaney
Chemistry–A European Journal 18 (34), 10562-10570, 2012
462012
Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity
CM Tron, IW McNae, M Nutley, DJ Clarke, A Cooper, MD Walkinshaw, ...
Journal of molecular biology 387 (1), 129-146, 2009
402009
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