| A functional role for Aβ in metal homeostasis? N‐truncation and high‐affinity copper binding M Mital, NE Wezynfeld, T Frączyk, MZ Wiloch, UE Wawrzyniak, A Bonna, ... Angewandte Chemie 127 (36), 10606-10610, 2015 | 133 | 2015 |
| Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids BR Groveman, ST Foliaki, CD Orru, G Zanusso, JA Carroll, B Race, ... Acta neuropathologica communications 7, 1-12, 2019 | 94 | 2019 |
| Copper binding is the governing determinant of prion protein turnover CL Haigh, K Edwards, DR Brown Molecular and Cellular Neuroscience 30 (2), 186-196, 2005 | 71 | 2005 |
| Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt–Jakob disease BR Groveman, NC Ferreira, ST Foliaki, RO Walters, CW Winkler, B Race, ... Scientific Reports 11 (1), 5165, 2021 | 64 | 2021 |
| Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection V Lewis, AF Hill, CL Haigh, GM Klug, CL Masters, VA Lawson, SJ Collins Journal of Neuropathology & Experimental Neurology 68 (10), 1125-1135, 2009 | 64 | 2009 |
| Prion protein reduces both oxidative and non‐oxidative copper toxicity CL Haigh, DR Brown Journal of neurochemistry 98 (3), 677-689, 2006 | 60 | 2006 |
| Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response CL Haigh, SC Drew, MP Boland, CL Masters, KJ Barnham, VA Lawson, ... Journal of cell science 122 (10), 1518-1528, 2009 | 52 | 2009 |
| PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site CL Haigh, VA Lewis, LJ Vella, CL Masters, AF Hill, VA Lawson, SJ Collins Cell research 19 (9), 1062-1078, 2009 | 50 | 2009 |
| Copper‐dependent co‐internalization of the prion protein and glypican‐1 F Cheng, J Lindqvist, CL Haigh, DR Brown, K Mani Journal of neurochemistry 98 (5), 1445-1457, 2006 | 44 | 2006 |
| Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain MP Boland, CR Hatty, F Separovic, AF Hill, DJ Tew, KJ Barnham, ... Journal of Biological Chemistry 285 (42), 32282-32292, 2010 | 41 | 2010 |
| Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases ST Foliaki, B Schwarz, BR Groveman, RO Walters, NC Ferreira, CD Orrų, ... Molecular brain 14, 1-23, 2021 | 39 | 2021 |
| Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro CL Haigh, AR McGlade, V Lewis, CL Masters, VA Lawson, SJ Collins Free Radical Biology and Medicine 51 (3), 594-608, 2011 | 37 | 2011 |
| Neutron reflectometry studies define prion protein N-terminal peptide membrane binding AP Le Brun, CL Haigh, SC Drew, M James, MP Boland, SJ Collins Biophysical journal 107 (10), 2313-2324, 2014 | 36 | 2014 |
| Copper, endoproteolytic processing of the prion protein and cell signalling CL Haigh, SY Marom, SJ Collins Front Biosci 15, 1086-104, 2010 | 32 | 2010 |
| Regulation of prion protein expression by noncoding regions of the Prnp gene CL Haigh, JA Wright, DR Brown Journal of Molecular Biology 368 (4), 915-927, 2007 | 31 | 2007 |
| Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons CW Winkler, TA Woods, BR Groveman, AB Carmody, EE Speranza, ... Journal of Neuroinflammation 16, 1-16, 2019 | 30 | 2019 |
| MEK1 transduces the prion protein N2 fragment antioxidant effects CL Haigh, AR McGlade, SJ Collins Cellular and molecular life sciences 72, 1613-1629, 2015 | 30 | 2015 |
| Pathogenic prion protein isoforms are not present in cerebral organoids generated from asymptomatic donors carrying the E200K mutation associated with familial prion disease ST Foliaki, BR Groveman, J Yuan, R Walters, S Zhang, P Tesar, W Zou, ... Pathogens 9 (6), 482, 2020 | 28 | 2020 |
| Near-infrared fluorescence imaging of apoptotic neuronal cell death in a live animal model of prion disease VA Lawson, CL Haigh, B Roberts, VB Kenche, HMJ Klemm, CL Masters, ... ACS Chemical Neuroscience 1 (11), 720-727, 2010 | 27 | 2010 |
| The prion protein N1 and N2 cleavage fragments bind to phosphatidylserine and phosphatidic acid; relevance to stress-protection responses CL Haigh, C Tumpach, SC Drew, SJ Collins PloS one 10 (8), e0134680, 2015 | 26 | 2015 |
Bradley GrovemanNIH/NIAIDVerified email at nih.gov
