| The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif LK Williams, X Zhang, S Caner, C Tysoe, NT Nguyen, J Wicki, ... Nature chemical biology 11 (9), 691-696, 2015 | 137 | 2015 |
| Rapid assembly of a library of lipophilic iminosugars via the thiol–ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease ED Goddard-Borger, MB Tropak, S Yonekawa, C Tysoe, DJ Mahuran, ... Journal of medicinal chemistry 55 (6), 2737-2745, 2012 | 87 | 2012 |
| Rapid discovery of potent and selective glycosidase-inhibiting de novo peptides SAK Jongkees, S Caner, C Tysoe, GD Brayer, SG Withers, H Suga Cell chemical biology 24 (3), 381-390, 2017 | 64 | 2017 |
| Potent human α-amylase inhibition by the β-defensin-like protein helianthamide C Tysoe, LK Williams, R Keyzers, NT Nguyen, C Tarling, J Wicki, ... ACS central science 2 (3), 154-161, 2016 | 48 | 2016 |
| Substrate-Triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA B Zhang, LJ Rajakovich, D Van Cura, EJ Blaesi, AJ Mitchell, CR Tysoe, ... Journal of the American Chemical Society 141 (37), 14510-14514, 2019 | 46 | 2019 |
| A Peroxodiiron(III/III) Intermediate Mediating Both N-Hydroxylation Steps in Biosynthesis of the N-Nitrosourea Pharmacophore of Streptozotocin by the Multi … MJ McBride, D Sil, TL Ng, AM Crooke, GE Kenney, CR Tysoe, B Zhang, ... Journal of the American Chemical Society 142 (27), 11818-11828, 2020 | 36 | 2020 |
| Fluorinated mechanism-based inhibitors: common themes and recent developments C Tysoe, S G Withers Current Topics in Medicinal Chemistry 14 (7), 865-874, 2014 | 30 | 2014 |
| Alpha-glucosidase and alpha-amylase inhibiting thiodiketopiperazines from the endophytic fungus Setosphaeria rostrata isolated from the medicinal plant Costus speciosus in Sri … RM Centko, PB Ratnaweera, C Tysoe, SG Withers, ED de Silva, ... Phytochemistry letters 22, 76-80, 2017 | 26 | 2017 |
| Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β … M Thonhofer, P Weber, AG Santana, C Tysoe, R Fischer, BM Pabst, ... Carbohydrate research 429, 71-80, 2016 | 23 | 2016 |
| Folding then binding vs folding through binding in macrocyclic peptide inhibitors of human pancreatic α-amylase L Goldbach, BJA Vermeulen, S Caner, M Liu, C Tysoe, L van Gijzel, ... ACS chemical biology 14 (8), 1751-1759, 2019 | 22 | 2019 |
| A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols M Schalli, P Weber, C Tysoe, BM Pabst, M Thonhofer, E Paschke, ... Bioorganic & Medicinal Chemistry Letters 27 (15), 3431-3435, 2017 | 19 | 2017 |
| Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy M Zoidl, B Müller, A Torvisco, C Tysoe, M Benazza, A Siriwardena, ... Bioorganic & Medicinal Chemistry Letters 24 (12), 2777-2780, 2014 | 18 | 2014 |
| The Staudinger/aza-Wittig/Grignard reaction as key step for the concise synthesis of 1-C-Alkyl-iminoalditol glycomimetics M Zoidl, AG Santana, A Torvisco, C Tysoe, A Siriwardena, SG Withers, ... Carbohydrate Research 429, 62-70, 2016 | 16 | 2016 |
| Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase CR Tysoe, S Caner, MB Calvert, A Win-Mason, GD Brayer, SG Withers Chemical Science 10 (48), 11073-11077, 2019 | 12 | 2019 |
| Structural dissection of helianthamide reveals the basis of its potent inhibition of human pancreatic α-amylase C Tysoe, SG Withers Biochemistry 57 (37), 5384-5387, 2018 | 12 | 2018 |
| N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant M Schalli, C Tysoe, R Fischer, BM Pabst, M Thonhofer, E Paschke, ... Carbohydrate research 443, 15-22, 2017 | 7 | 2017 |
| A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors R Lebl, M Thonhofer, C Tysoe, BM Pabst, M Schalli, P Weber, E Paschke, ... Carbohydrate research 442, 31-40, 2017 | 7 | 2017 |
| C-5a-substituted validamine type glycosidase inhibitors M Schalli, A Wolfsgruber, AG Santana, C Tysoe, R Fischer, AE Stütz, ... Carbohydrate research 440, 1-9, 2017 | 7 | 2017 |
| Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine P Weber, M Thonhofer, S Averill, GJ Davies, AG Santana, P Müller, ... Molecules 25 (17), 4025, 2020 | 5 | 2020 |
| Fungal Glycolipid Hydrolase Inhibitors and Their Effect on Cryptococcus neoformans AG Santana, C Tysoe, G Hu, J Kronstad, ED Goddard‐Borger, SG Withers Chembiochem 18 (3), 284-290, 2017 | 5 | 2017 |
