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Joseph D. Powers
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Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues
A Leonard, A Bertero, JD Powers, KM Beussman, S Bhandari, M Regnier, ...
Journal of molecular and cellular cardiology 118, 147-158, 2018
1532018
Myosin filament activation in the heart is tuned to the mechanical task
M Reconditi, M Caremani, F Pinzauti, JD Powers, T Narayanan, ...
Proceedings of the National Academy of Sciences 114 (12), 3240-3245, 2017
1262017
The sliding filament theory since Andrew Huxley: multiscale and multidisciplinary muscle research
JD Powers, SA Malingen, M Regnier, TL Daniel
Annual review of biophysics 50, 373-400, 2021
422021
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin
JD Powers, CC Yuan, KJ McCabe, JD Murray, MC Childers, GV Flint, ...
Proceedings of the National Academy of Sciences 116 (23), 11502-11507, 2019
372019
Inotropic interventions do not change the resting state of myosin motors during cardiac diastole
M Caremani, F Pinzauti, JD Powers, S Governali, T Narayanan, ...
Journal of General Physiology 151 (1), 53-65, 2019
372019
Minimum number of myosin motors accounting for shortening velocity under zero load in skeletal muscle
L Fusi, V Percario, E Brunello, M Caremani, P Bianco, JD Powers, ...
The Journal of physiology 595 (4), 1127-1142, 2017
372017
A spatially explicit model shows how titin stiffness modulates muscle mechanics and energetics
JD Powers, CD Williams, M Regnier, TL Daniel
Integrative and comparative biology 58 (2), 186-193, 2018
242018
Contracting striated muscle has a dynamic I‐band spring with an undamped stiffness 100 times larger than the passive stiffness
JD Powers, P Bianco, I Pertici, M Reconditi, V Lombardi, G Piazzesi
The Journal of Physiology 598 (2), 331-345, 2020
232020
Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts
JD Powers, KB Kooiker, AB Mason, AE Teitgen, GV Flint, JC Tardiff, ...
JCI insight 5 (20), 2020
212020
The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions
SM Mijailovich, M Prodanovic, C Poggesi, JD Powers, J Davis, ...
Journal of molecular and cellular cardiology 155, 112-124, 2021
172021
Biomechanical signals regulating the structure of the heart
JD Powers, AD McCulloch
Current Opinion in Physiology 25, 100482, 2022
102022
Subcellular remodeling in filamin C deficient mouse hearts impairs myocyte tension development during progression of dilated cardiomyopathy
JD Powers, NJ Kirkland, C Liu, SS Razu, X Fang, AJ Engler, J Chen, ...
International journal of molecular sciences 23 (2), 871, 2022
92022
Multiscale models of cardiac muscle biophysics and tissue remodeling in hypertrophic cardiomyopathies
Y Aboelkassem, JD Powers, KJ McCabe, AD McCulloch
Current opinion in biomedical engineering 11, 35-44, 2019
92019
The predicted role of steric specificity in crowding-mediated effects on reversible biomolecular association
JD Powers, BT Castle, DJ Odde
Physical Biology 12 (6), 066004, 2015
52015
Modulation of calcium sensitivity and twitch contractions in cardiac muscle with troponin-C mutations: simulations and experiments
SM Mijailovich, M Prodanovic, L Vasovic, B Stojanovic, M Maric, ...
Biophysical Journal 116 (3), 116a, 2019
42019
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations
A Asencio, S Malingen, KB Kooiker, JD Powers, J Davis, T Daniel, ...
Journal of General Physiology 155 (5), e202213291, 2023
12023
Nuclear mechanosignaling in striated muscle diseases
B Zhang, JD Powers, AD McCulloch, NC Chi
Frontiers in Physiology 14, 1126111, 2023
12023
Cardiac‐specific Deletion of Filamin C Decouples Myocyte Contractility and Calcium Handling in Adult Mice
JD Powers, C Liu, X Fang, JH Omens, J Chen, AD McCulloch
The FASEB Journal 34 (S1), 1-1, 2020
12020
Influence of cTn Ca2+ binding properties and cooperative mechanisms on cardiac muscle contractile dynamics
SM Mijailovich, D Nedic, B Stojanovic, JD Powers, J Davis, MA Geeves, ...
Biophysical Journal 114 (3), 500a, 2018
12018
Evidence for an I-Band Spring that is Tuned to the Length of the Skeletal Muscle Sarcomere
JD Powers, M Reconditi, L Fusi, E Brunello, V Lombardi, G Piazzesi
Biophysical Journal 112 (3), 181a, 2017
12017
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Articles 1–20