H. Leighton Grimes
H. Leighton Grimes
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Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
RC Muise-Helmericks, HL Grimes, A Bellacosa, SE Malstrom, PN Tsichlis, ...
Journal of Biological Chemistry 273 (45), 29864-29872, 1998
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
PA Northcott, C Lee, T Zichner, AM Stütz, S Erkek, D Kawauchi, DJH Shih, ...
Nature 511 (7510), 428-434, 2014
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
NN Ahmed, HL Grimes, A Bellacosa, TO Chan, PN Tsichlis
Proceedings of the National Academy of Sciences 94 (8), 3627-3632, 1997
Suppression of IL7Rα transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival
JH Park, Q Yu, B Erman, JS Appelbaum, D Montoya-Durango, HL Grimes, ...
Immunity 21 (2), 289-302, 2004
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
A Olsson, M Venkatasubramanian, VK Chaudhri, BJ Aronow, ...
Nature 537 (7622), 698-702, 2016
Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2
RE Person, FQ Li, Z Duan, KF Benson, J Wechsler, HA Papadaki, ...
Nature genetics 34 (3), 308-312, 2003
Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor
PA Zweidler-McKay, HL Grimes, MM Flubacher, PN Tsichlis
Molecular and cellular biology 16 (8), 4024-4034, 1996
Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes
A Yáńez, SG Coetzee, A Olsson, DE Muench, BP Berman, DJ Hazelett, ...
Immunity 47 (5), 890-902. e4, 2017
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells
BW Sutherland, J Kucab, J Wu, C Lee, MCU Cheang, E Yorida, D Turbin, ...
Oncogene 24 (26), 4281-4292, 2005
The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal
HL Grimes, TO Chan, PA Zweidler-McKay, B Tong, PN Tsichlis
Molecular and cellular biology 16 (11), 6263-6272, 1996
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival
D Wallis, M Hamblen, Y Zhou, KJT Venken, A Schumacher, HL Grimes, ...
Oxford University Press for The Company of Biologists Limited 130 (1), 221-232, 2003
Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis
S Wojciechowski, P Tripathi, T Bourdeau, L Acero, HL Grimes, JD Katz, ...
The Journal of experimental medicine 204 (7), 1665-1675, 2007
Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
R Popovic, LE Riesbeck, CS Velu, A Chaubey, J Zhang, NJ Achille, ...
Blood, The Journal of the American Society of Hematology 113 (14), 3314-3322, 2009
Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein
CB Gilks, SE Bear, HL Grimes, PN Tsichlis
Molecular and Cellular Biology 13 (3), 1759-1768, 1993
Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells
S Goyama, J Schibler, L Cunningham, Y Zhang, Y Rao, N Nishimoto, ...
The Journal of clinical investigation 123 (9), 3876-3888, 2013
Gfi1 regulates miR-21 and miR-196b to control myelopoiesis
CS Velu, AM Baktula, HL Grimes
Blood, The Journal of the American Society of Hematology 113 (19), 4720-4728, 2009
P63 expression in lung carcinoma: a tissue microarray study of 408 cases
NHC Au, AM Gown, M Cheang, D Huntsman, E Yorida, WM Elliott, J Flint, ...
Applied Immunohistochemistry & Molecular Morphology 12 (3), 240-247, 2004
Gfi1 Coordinates Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1
Z Duan, A Zarebski, D Montoya-Durango, HL Grimes, M Horwitz
Molecular and cellular biology 25 (23), 10338-10351, 2005
The Human Cell Atlas bone marrow single-cell interactive web portal
SB Hay, K Ferchen, K Chetal, HL Grimes, N Salomonis
Experimental hematology 68, 51-61, 2018
Combinatorial single-cell analyses of granulocyte-monocyte progenitor heterogeneity reveals an early uni-potent neutrophil progenitor
I Kwok, E Becht, Y Xia, M Ng, YC Teh, L Tan, M Evrard, JLY Li, HTN Tran, ...
Immunity 53 (2), 303-318. e5, 2020
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