Jack A. Dunkle
Jack A. Dunkle
Associate Professor of Chemistry and Biochemistry, University of Alabama
Verified email at - Homepage
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Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action
JA Dunkle, L Xiong, AS Mankin, JHD Cate
Proceedings of the national academy of sciences 107 (40), 17152-17157, 2010
Structures of the bacterial ribosome in classical and hybrid states of tRNA binding
JA Dunkle, L Wang, MB Feldman, A Pulk, VB Chen, GJ Kapral, J Noeske, ...
Science 332 (6032), 981-984, 2011
Structures of the ribosome in intermediate states of ratcheting
W Zhang, JA Dunkle, JHD Cate
Science 325 (5943), 1014-1017, 2009
The mechanisms of RNA SHAPE chemistry
JL McGinnis, JA Dunkle, JHD Cate, KM Weeks
Journal of the American Chemical Society 134 (15), 6617-6624, 2012
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis
B Llano-Sotelo, J Dunkle, D Klepacki, W Zhang, P Fernandes, JHD Cate, ...
Antimicrobial agents and chemotherapy 54 (12), 4961-4970, 2010
Ribosome structure and dynamics during translocation and termination
JA Dunkle, JHD Cate
Annual review of biophysics 39, 227-244, 2010
Structural insights into+ 1 frameshifting promoted by expanded or modification-deficient anticodon stem loops
T Maehigashi, JA Dunkle, SJ Miles, CM Dunham
Proceedings of the National Academy of Sciences 111 (35), 12740-12745, 2014
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA
JA Dunkle, K Vinal, PM Desai, N Zelinskaya, M Savic, DM West, GL Conn, ...
Proceedings of the National Academy of Sciences 111 (17), 6275-6280, 2014
Molecular determinants for CRISPR RNA maturation in the Cas10–Csm complex and roles for non-Cas nucleases
FC Walker, L Chou-Zheng, JA Dunkle, A Hatoum-Aslan
Nucleic acids research 45 (4), 2112-2123, 2017
Defining the mRNA recognition signature of a bacterial toxin protein
MA Schureck, JA Dunkle, T Maehigashi, SJ Miles, CM Dunham
Proceedings of the National Academy of Sciences 112 (45), 13862-13867, 2015
Mechanism of tRNA-mediated+ 1 ribosomal frameshifting
S Hong, S Sunita, T Maehigashi, ED Hoffer, JA Dunkle, CM Dunham
Proceedings of the National Academy of Sciences 115 (44), 11226-11231, 2018
Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state
CE Fagan, JA Dunkle, T Maehigashi, MN Dang, A Devaraj, SJ Miles, ...
Proceedings of the National Academy of Sciences 110 (24), 9716-9721, 2013
Regulation of cyclic oligoadenylate synthesis by the Staphylococcus epidermidis Cas10-Csm complex
M Nasef, MC Muffly, AB Beckman, SJ Rowe, FC Walker, A Hatoum-Aslan, ...
Rna 25 (8), 948-962, 2019
Structural insights into translational recoding by frameshift suppressor tRNASufJ
CE Fagan, T Maehigashi, JA Dunkle, SJ Miles, CM Dunham
RNA 20 (12), 1944-1954, 2014
Mechanisms of mRNA frame maintenance and its subversion during translation of the genetic code
JA Dunkle, CM Dunham
Biochimie 114, 90-96, 2015
Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues
M Blahut, CE Wise, MR Bruno, G Dong, TM Makris, PA Frantom, ...
Journal of Biological Chemistry 294 (33), 12444-12458, 2019
Structural evidence for dimer-interface-driven regulation of the type II cysteine desulfurase, SufS
JA Dunkle, MR Bruno, FW Outten, PA Frantom
Biochemistry 58 (6), 687-696, 2018
The packing of ribosomes in crystals and polysomes
JA Dunkle, JHD Cate
Ribosomes, 65-73, 2011
Structural evidence for a latch mechanism regulating access to the active site of SufS-family cysteine desulfurases
JA Dunkle, MR Bruno, PA Frantom
Acta Crystallographica Section D: Structural Biology 76 (3), 291-301, 2020
Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition
SJ Rowe, RJ Mecaskey, M Nasef, RC Talton, RE Sharkey, JC Halliday, ...
Journal of Biological Chemistry 295 (51), 17476-17485, 2020
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