Total synthesis of jadomycin A and a carbasugar analogue of jadomycin B M Shan, EU Sharif, GA O'Doherty Angewandte Chemie International Edition 49 (49), 9492-9495, 2010 | 88 | 2010 |
De novo asymmetric synthesis of the mezzettiaside family of natural products via the iterative use of a dual B-/Pd-catalyzed glycosylation GA áO'Doherty Chemical Science 5 (6), 2230-2234, 2014 | 83 | 2014 |
Discovery of AB680: a potent and selective inhibitor of CD73 KV Lawson, J Kalisiak, EA Lindsey, ET Newcomb, MR Leleti, L Debien, ... Journal of Medicinal Chemistry 63 (20), 11448-11468, 2020 | 59 | 2020 |
Merremoside D: De Novo Synthesis of the Purported Structure, NMR Analysis, and Comparison of Spectral Data EU Sharif, HYL Wang, NG Akhmedov, GA O’Doherty Organic letters 16 (2), 492-495, 2014 | 44 | 2014 |
C3′/C4′‐Stereochemical Effects of Digitoxigenin α‐L‐/α‐D‐Glycoside in Cancer Cytotoxicity JW Hinds, SB McKenna, EU Sharif, HYL Wang, NG Akhmedov, ... ChemMedChem 8 (1), 63-69, 2013 | 35 | 2013 |
Biosynthesis and total synthesis studies on the jadomycin family of natural products EU Sharif, GA O'Doherty European journal of organic chemistry 2012 (11), 2095-2108, 2012 | 34 | 2012 |
Discovery of potent and selective PI3Kγ inhibitors SL Drew, R Thomas-Tran, JW Beatty, J Fournier, KV Lawson, DH Miles, ... Journal of Medicinal Chemistry 63 (19), 11235-11257, 2020 | 32 | 2020 |
Roles of the Synergistic Reductive O-Methyltransferase GilM and of O-Methyltransferase GilMT in the Gilvocarcin Biosynthetic Pathway N Tibrewal, TE Downey, SG Van Lanen, E Ul Sharif, GA O’Doherty, ... Journal of the American Chemical Society 134 (30), 12402-12405, 2012 | 29 | 2012 |
New catalytic asymmetric formation of oxygen heterocycles bearing nucleoside bases at the anomeric carbon BM Trost, S Xu, EU Sharif Journal of the American Chemical Society 141 (26), 10199-10204, 2019 | 20 | 2019 |
Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors EU Sharif, J Kalisiak, KV Lawson, DH Miles, E Newcomb, EA Lindsey, ... Journal of Medicinal Chemistry, 2021 | 19 | 2021 |
Modulators of 5′-nucleotidase, ecto and the use thereof LPP Debien, JC Jaen, J Kalisiak, KV Lawson, MR Leleti, EA Lindsey, ... US Patent 10,239,912, 2019 | 18 | 2019 |
Discovery of potent and selective 7-azaindole isoindolinone-based PI3Kγ inhibitors DH Miles, X Yan, R Thomas-Tran, J Fournier, EU Sharif, SL Drew, G Mata, ... ACS Medicinal Chemistry Letters 11 (11), 2244-2252, 2020 | 15 | 2020 |
Combining adenosine receptor inhibition with AB928 and chemotherapy results in greater immune activation and tumor control MJ Walters, D Piovesan, J Tan, D DiRenzo, F Yin, D Miles, MR Leleti, ... Cancer Research 78 (13_Supplement), 5556-5556, 2018 | 15 | 2018 |
Modulators of 5′-nucleotidase, ecto and the use thereof LPP Debien, JC Jaen, J Kalisiak, KV Lawson, MR Leleti, EA Lindsey, ... US Patent 10,981,944, 2021 | 13 | 2021 |
Characterization of the potent and selective A2aR antagonist AB928 for the treatment of cancer MJ Walters, JB Tan, A Becker, F Yi, T Park, MR Leleti, B Rosen, E Sharif, ... Cancer Research 77 (13_Supplement), 4572-4572, 2017 | 11 | 2017 |
Azolopyrimidine for the treatment of cancer-related disorders J Beatty, L Debien, J Jeffrey, MR Leleti, D Mandal, D Miles, J Powers, ... US Patent 10,399,962, 2019 | 10 | 2019 |
Design, synthesis, and structure–activity relationship optimization of pyrazolopyrimidine amide inhibitors of phosphoinositide 3-kinase γ (PI3Kγ) G Mata, DH Miles, SL Drew, J Fournier, KV Lawson, AK Mailyan, ... Journal of Medicinal Chemistry 65 (2), 1418-1444, 2021 | 9 | 2021 |
Ruthenium‐Catalyzed Multicomponent Reactions: Access to α‐Silyl‐β‐Hydroxy Vinylsilanes, Stereodefined 1, 3‐Dienes, and Cyclohexenes BM Trost, DC Koester, EU Sharif Chemistry–A European Journal 22 (8), 2634-2638, 2016 | 9 | 2016 |
Regioselective bromination: an approach to the D-ring of the gilvocarcins EU Sharif, GA O’Doherty Heterocycles 88, 1275-1285, 2014 | 8 | 2014 |
Abstract A162: AB928, a dual antagonist of the A2aR and A2bR adenosine receptors, relieves adenosine-mediated immune suppression D DiRenzo, D Piovesan, J Tan, DH Miles, MR Leleti, T Park, F Soriano, ... Cancer Immunology Research 7 (2_Supplement), A162-A162, 2019 | 7 | 2019 |