Yuhui Chen
Yuhui Chen
UNC Lineberger Comprehensive Cancer Center
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Antitumor responses in the absence of toxicity in solid tumors by targeting B7-H3 via chimeric antigen receptor T cells
H Du, K Hirabayashi, S Ahn, NP Kren, SA Montgomery, X Wang, ...
Cancer cell 35 (2), 221-237. e8, 2019
Inducible caspase-9 selectively modulates the toxicities of CD19-specific chimeric antigen receptor-modified T cells
I Diaconu, B Ballard, M Zhang, Y Chen, J West, G Dotti, B Savoldo
Molecular Therapy 25 (3), 580-592, 2017
Interleukin-23 engineering improves CAR T cell function in solid tumors
X Ma, P Shou, C Smith, Y Chen, H Du, C Sun, N Porterfield Kren, ...
Nature biotechnology 38 (4), 448-459, 2020
Eradication of neuroblastoma by T cells redirected with an optimized Gd2-specific chimeric antigen receptor and interleukin-15gd2. car-Ts-Expressing Il15 eradicate neuroblastoma
Y Chen, C Sun, E Landoni, L Metelitsa, G Dotti, B Savoldo
Clinical cancer research 25 (9), 2915-2924, 2019
Immunological synapse predicts effectiveness of chimeric antigen receptor cells
W Xiong, Y Chen, X Kang, Z Chen, P Zheng, YH Hsu, JH Jang, L Qin, ...
Molecular Therapy 26 (4), 963-975, 2018
NKT Cells Coexpressing a GD2-Specific Chimeric Antigen Receptor and IL15 Show Enhanced In Vivo Persistence and Antitumor Activity against NeuroblastomaCAR-NKTs Mediate Long …
X Xu, W Huang, A Heczey, D Liu, L Guo, M Wood, J Jin, AN Courtney, ...
Clinical Cancer Research 25 (23), 7126-7138, 2019
Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy
S Pellegatta, B Savoldo, N Di Ianni, C Corbetta, Y Chen, M Patané, C Sun, ...
Science translational medicine 10 (430), eaao2731, 2018
THEMIS-SHP1 recruitment by 4-1BB tunes LCK-mediated priming of chimeric antigen receptor-redirected T cells
C Sun, P Shou, H Du, K Hirabayashi, Y Chen, LE Herring, S Ahn, Y Xu, ...
Cancer Cell 37 (2), 216-225. e6, 2020
Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells
S Wang, MF He, YH Chen, MY Wang, XM Yu, J Bai, HY Zhu, YY Wang, ...
Cell death & disease 4 (10), e856-e856, 2013
CD30-Redirected Chimeric Antigen Receptor T Cells Target CD30+ and CD30 Embryonal Carcinoma via Antigen-Dependent and Fas/FasL Interactions
LK Hong, Y Chen, CC Smith, SA Montgomery, BG Vincent, G Dotti, ...
Cancer immunology research 6 (10), 1274-1287, 2018
Prevalence of heterotypic tumor/immune cell-in-cell structure in vitro and in vivo leading to formation of aneuploidy
Y Chen, S Wang, M He, Y Wang, H Zhao, H Zhu, X Yu, J Ma, X Che, ...
PLoS One 8 (3), e59418, 2013
In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures
C Ni, Y Chen, M Zeng, R Pei, Y Du, L Tang, M Wang, Y Hu, H Zhu, M He, ...
Cell research 25 (7), 785-800, 2015
GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision
K Wang, Y Chen, S Ahn, M Zheng, E Landoni, G Dotti, B Savoldo, Z Han
Nature cancer 1 (10), 990-997, 2020
Dual-targeting CAR-T cells with optimal co-stimulation and metabolic fitness enhance antitumor activity and prevent escape in solid tumors
K Hirabayashi, H Du, Y Xu, P Shou, X Zhou, G Fucá, E Landoni, C Sun, ...
Nature cancer 2 (9), 904-918, 2021
Molecular mechanisms of functional natural killer deficiency in patients with partial DiGeorge syndrome
P Zheng, LM Noroski, IC Hanson, Y Chen, ME Lee, Y Huang, MX Zhu, ...
Journal of Allergy and Clinical Immunology 135 (5), 1293-1302, 2015
Implication of cell-in-cell structures in the transmission of HIV to epithelial cells
C Ni, L Huang, Y Chen, M He, Y Hu, S Liu, X Fang, J Li, Q Sun, X Wang
Cell research 25 (11), 1265-1268, 2015
Super-resolution imaging of the natural killer cell immunological synapse on a glass-supported planar lipid bilayer
P Zheng, G Bertolet, Y Chen, S Huang, D Liu
JoVE (Journal of Visualized Experiments), e52502, 2015
B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses
EJ Pone, T Lam, Z Lou, R Wang, Y Chen, D Liu, AL Edinger, Z Xu, ...
The Journal of Immunology 194 (7), 3065-3078, 2015
A high-avidity T-cell receptor redirects natural killer T-cell specificity and outcompetes the endogenous invariant T-cell receptor
E Landoni, CC Smith, G Fucá, Y Chen, C Sun, BG Vincent, LS Metelitsa, ...
Cancer immunology research 8 (1), 57-69, 2020
Constitutive and TNF-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy
S Pellegatta, B Savoldo, N Di Ianni, C Corbetta, Y Chen, M Patané, C Sun, ...
Sci. Transl. Med 10, 2013
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