| Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast RS McIsaac, BL Oakes, X Wang, KA Dummit, D Botstein, MB Noyes Nucleic acids research 41 (4), e57-e57, 2013 | 190 | 2013 |
| Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae RS McIsaac, SJ Silverman, MN McClean, PA Gibney, J Macinskas, ... Molecular biology of the cell 22 (22), 4447-4459, 2011 | 177 | 2011 |
| Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen I Thievessen, N Fakhri, J Steinwachs, V Kraus, RS McIsaac, L Gao, ... The FASEB Journal 29 (11), 4555, 2015 | 132 | 2015 |
| Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae RS McIsaac, PA Gibney, SS Chandran, KR Benjamin, D Botstein Nucleic acids research 42 (6), e48-e48, 2014 | 127 | 2014 |
| Directed evolution of a far-red fluorescent rhodopsin RS McIsaac, MKM Engqvist, T Wannier, AZ Rosenthal, L Herwig, ... Proceedings of the National Academy of Sciences 111 (36), 13034-13039, 2014 | 114 | 2014 |
| Directed evolution of Gloeobacter violaceus rhodopsin spectral properties MKM Engqvist, RS McIsaac, P Dollinger, NC Flytzanis, M Abrams, ... Journal of molecular biology 427 (1), 205-220, 2015 | 110 | 2015 |
| From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span RS McIsaac, KN Lewis, PA Gibney, R Buffenstein Annals of the New York Academy of Sciences 1363 (1), 155-170, 2016 | 72 | 2016 |
| A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast DG Hendrickson, I Soifer, BJ Wranik, G Kim, M Robles, PA Gibney, ... elife 7, e39911, 2018 | 66 | 2018 |
| Recent advances in engineering microbial rhodopsins for optogenetics RS McIsaac, CN Bedbrook, FH Arnold Current opinion in structural biology 33, 8-15, 2015 | 62 | 2015 |
| A genome‐scale yeast library with inducible expression of individual genes Y Arita, G Kim, Z Li, H Friesen, G Turco, RY Wang, D Climie, M Usaj, ... Molecular Systems Biology 17 (6), e10207, 2021 | 60 | 2021 |
| Learning causal networks using inducible transcription factors and transcriptome‐wide time series SR Hackett, EA Baltz, M Coram, BJ Wranik, G Kim, A Baker, M Fan, ... Molecular systems biology 16 (3), e9174, 2020 | 57 | 2020 |
| Unraveling the message: insights into comparative genomics of the naked mole-rat KN Lewis, I Soifer, E Melamud, M Roy, RS McIsaac, M Hibbs, ... Mammalian Genome 27, 259-278, 2016 | 52 | 2016 |
| Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway RS McIsaac, AA Petti, HJ Bussemaker, D Botstein Molecular biology of the cell 23 (15), 2993-3007, 2012 | 51 | 2012 |
| Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast MJ Hickman, AA Petti, O Ho-Shing, SJ Silverman, RS McIsaac, TA Lee, ... Molecular biology of the cell 22 (21), 4192-4204, 2011 | 51 | 2011 |
| Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway AA Petti, RS McIsaac, O Ho-Shing, HJ Bussemaker, D Botstein Molecular biology of the cell 23 (15), 3008-3024, 2012 | 49 | 2012 |
| Monomerization of far-red fluorescent proteins TM Wannier, SK Gillespie, N Hutchins, RS McIsaac, SY Wu, Y Shen, ... Proceedings of the National Academy of Sciences 115 (48), E11294-E11301, 2018 | 36 | 2018 |
| Dual threshold optimization and network inference reveal convergent evidence from TF binding locations and TF perturbation responses Y Kang, NR Patel, C Shively, PS Recio, X Chen, BJ Wranik, G Kim, ... Genome research 30 (3), 459-471, 2020 | 30 | 2020 |
| An estradiol‐inducible promoter enables fast, graduated control of gene expression in fission yeast MJ Ohira, DG Hendrickson, R Scott McIsaac, N Rhind Yeast 34 (8), 323-334, 2017 | 25 | 2017 |
| Visualization and analysis of mRNA molecules using fluorescence in situ hybridization in Saccharomyces cerevisiae RS McIsaac, SJ Silverman, L Parsons, P Xu, R Briehof, MN McClean, ... Journal of visualized experiments: JoVE, 50382, 2013 | 25 | 2013 |
| Simultaneous profiling of DNA accessibility and gene expression dynamics with ATAC-seq and RNA-seq DG Hendrickson, I Soifer, BJ Wranik, D Botstein, R Scott McIsaac Computational Cell Biology: Methods and Protocols, 317-333, 2018 | 24 | 2018 |
