John Reyes Ussher
John Reyes Ussher
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta
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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ...
Cell metabolism 7 (1), 45-56, 2008
Myocardial fatty acid metabolism in health and disease
GD Lopaschuk, JR Ussher, CDL Folmes, JS Jaswal, WC Stanley
Physiological Reviews 90 (1), 207-258, 2010
Cardiovascular Biology of the Incretin System
JR Ussher, DJ Drucker
Endocrine Reviews, 2012
Targeting fatty acid and carbohydrate oxidation-A novel therapeutic intervention in the ischemic and failing heart
JS Jaswal, W Keung, W Wang, JR Ussher, GD Lopaschuk
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2011
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption
JR Ussher, TR Koves, VJJ Cadete, L Zhang, JS Jaswal, SJ Swyrd, ...
Diabetes 59 (10), 2453-2464, 2010
Cardiovascular actions of incretin-based therapies
JR Ussher, DJ Drucker
Circulation research 114 (11), 1788-1803, 2014
Gut microbiota metabolism of L-carnitine and cardiovascular risk
JR Ussher, GD Lopaschuk, A Arduini
Atherosclerosis 231 (2), 456-461, 2013
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury
JR Ussher, W Wang, M Gandhi, W Keung, V Samokhvalov, T Oka, ...
Cardiovascular research 94 (2), 359-369, 2012
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function
R Basu, GY Oudit, X Wang, L Zhang, JR Ussher, GD Lopaschuk, Z Kassiri
American Journal of Physiology-Heart and Circulatory Physiology 297 (6 …, 2009
Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy
L Zhang, JS Jaswal, JR Ussher, S Sankaralingam, C Wagg, M Zaugg, ...
Circulation: Heart Failure 6 (5), 1039-1048, 2013
Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase
JR Ussher, TR Koves, JS Jaswal, L Zhang, O Ilkayeva, JRB Dyck, ...
Diabetes 58 (8), 1766-1775, 2009
The emerging role of metabolomics in the diagnosis and prognosis of cardiovascular disease
JR Ussher, S Elmariah, RE Gerszten, JRB Dyck
Journal of the American College of Cardiology 68 (25), 2850-2870, 2016
Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation
L Zhang, JR Ussher, T Oka, VJJ Cadete, C Wagg, GD Lopaschuk
Cardiovascular research 89 (1), 148-156, 2011
Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice
W Keung, JR Ussher, JS Jaswal, M Raubenheimer, VHM Lam, CS Wagg, ...
Diabetes 62 (3), 711-720, 2013
Lipotoxicity in obesity and diabetes-related cardiac dysfunction
I Zlobine, K Gopal, JR Ussher
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2016
The malonyl CoA axis as a potential target for treating ischaemic heart disease
JR Ussher, GD Lopaschuk
Cardiovascular research 79 (2), 259-268, 2008
Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection
JR Ussher, LL Baggio, JE Campbell, EE Mulvihill, M Kim, MG Kabir, ...
Molecular metabolism 3 (5), 507-517, 2014
Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion
JR Ussher, GD Lopaschuk
Basic research in cardiology 104 (2), 203-210, 2009
Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite
GD Lopaschuk, JR Ussher, JS Jaswal
Pharmacological Reviews 62 (2), 237-264, 2010
TCF1 links GIPR signaling to the control of beta cell function and survival
JE Campbell, JR Ussher, EE Mulvihill, J Kolic, LL Baggio, X Cao, Y Liu, ...
Nature medicine 22 (1), 84-90, 2016
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