| Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities R Cannalire, C Cerchia, AR Beccari, FS Di Leva, V Summa Journal of medicinal chemistry 65 (4), 2716-2746, 2020 | 180 | 2020 |
| Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors C D’Amore, FS Di Leva, V Sepe, B Renga, C Del Gaudio, MV D’Auria, ... Journal of Medicinal Chemistry 57 (3), 937-954, 2014 | 97 | 2014 |
| Mechanistic insight into ligand binding to G-quadruplex DNA FS Di Leva, E Novellino, A Cavalli, M Parrinello, V Limongelli Nucleic acids research 42 (9), 5447-5455, 2014 | 90 | 2014 |
| Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides JD Hegemann, M De Simone, M Zimmermann, TA Knappe, X Xie, ... Journal of Medicinal Chemistry 57 (13), 5829-5834, 2014 | 88 | 2014 |
| Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives A Corona, FS Di Leva, S Thierry, L Pescatori, G Cuzzucoli Crucitti, ... Antimicrobial agents and chemotherapy 58 (10), 6101-6110, 2014 | 77 | 2014 |
| Biselectivity of isoDGR peptides for fibronectin binding integrin subtypes α5β1 and αvβ6: conformational control through flanking amino acids A Bochen, UK Marelli, E Otto, D Pallarola, C Mas-Moruno, FS Di Leva, ... Journal of medicinal chemistry 56 (4), 1509-1519, 2013 | 76 | 2013 |
| Stable peptides instead of stapled peptides: highly potent αvβ6‐selective integrin ligands OV Maltsev, UK Marelli, TG Kapp, FS Di Leva, S Di Maro, M Nieberler, ... Angewandte Chemie International Edition 55 (4), 1535-1539, 2016 | 74 | 2016 |
| Modification on ursodeoxycholic acid (UDCA) scaffold. Discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1) V Sepe, B Renga, C Festa, C D’Amore, D Masullo, S Cipriani, FS Di Leva, ... Journal of medicinal chemistry 57 (18), 7687-7701, 2014 | 72 | 2014 |
| Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase R Costi, M Métifiot, S Chung, G Cuzzucoli Crucitti, K Maddali, L Pescatori, ... Journal of Medicinal Chemistry 57 (8), 3223-3234, 2014 | 66 | 2014 |
| Monothiocarbamates strongly inhibit carbonic anhydrases in vitro and possess intraocular pressure lowering activity in an animal model of glaucoma D Vullo, M Durante, FS Di Leva, S Cosconati, E Masini, A Scozzafava, ... Journal of Medicinal Chemistry 59 (12), 5857-5867, 2016 | 62 | 2016 |
| Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological … FS Di Leva, C Festa, C D’Amore, S De Marino, B Renga, MV D’Auria, ... Journal of Medicinal Chemistry 56 (11), 4701-4717, 2013 | 60 | 2013 |
| State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders B Pagano, S Cosconati, V Gabelica, L Petraccone, S De Tito, L Marinelli, ... Current pharmaceutical design 18 (14), 1880-1899, 2012 | 57 | 2012 |
| Protein flexibility in virtual screening: the BACE-1 case study S Cosconati, L Marinelli, FS Di Leva, V La Pietra, A De Simone, F Mancini, ... Journal of chemical information and modeling 52 (10), 2697-2704, 2012 | 55 | 2012 |
| Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: A Suitable Scaffold for the Development of Noncamptothecin Topoisomerase I (Top1) Inhibitors S Taliani, I Pugliesi, E Barresi, S Salerno, C Marchand, K Agama, ... Journal of medicinal chemistry 56 (18), 7458-7462, 2013 | 52 | 2013 |
| N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase L Pescatori, M Métifiot, S Chung, T Masoaka, G Cuzzucoli Crucitti, ... Journal of medicinal chemistry 58 (11), 4610-4623, 2015 | 47 | 2015 |
| Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence FS Di Leva, P Zizza, C Cingolani, C D’Angelo, B Pagano, J Amato, ... Journal of Medicinal Chemistry 56 (23), 9646-9654, 2013 | 47 | 2013 |
| Pharmacophoric modifications lead to superpotent αvβ3 integrin ligands with suppressed α5β1 activity S Neubauer, F Rechenmacher, R Brimioulle, FS Di Leva, A Bochen, ... Journal of medicinal chemistry 57 (8), 3410-3417, 2014 | 41 | 2014 |
| Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists S De Marino, A Carino, D Masullo, C Finamore, S Marchianò, S Cipriani, ... Scientific Reports 7 (1), 43290, 2017 | 40 | 2017 |
| The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II JD Hegemann, CD Fage, S Zhu, K Harms, FS Di Leva, E Novellino, ... Molecular BioSystems 12 (4), 1106-1109, 2016 | 40 | 2016 |
| Bioinformatics and biosimulations as toolbox for peptides and peptidomimetics design: where are we? I D’Annessa, FS Di Leva, A La Teana, E Novellino, V Limongelli, ... Frontiers in Molecular Biosciences 7, 66, 2020 | 39 | 2020 |
