MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival K Mallilankaraman, P Doonan, C Cárdenas, HC Chandramoorthy, ... Cell 151 (3), 630-644, 2012 | 681 | 2012 |
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation RK Gandhirajan, S Meng, HC Chandramoorthy, K Mallilankaraman, ... The Journal of clinical investigation 123 (2), 2013 | 226 | 2013 |
MICU1 motifs define mitochondrial calcium uniporter binding and activity NE Hoffman, HC Chandramoorthy, S Shamugapriya, X Zhang, S Rajan, ... Cell reports 5 (6), 1576-1588, 2013 | 150 | 2013 |
Small molecule inhibitors of Wnt/β-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo RK Gandhirajan, PA Staib, K Minke, I Gehrke, G Plickert, A Schlösser, ... Neoplasia 12 (4), 326-IN6, 2010 | 141 | 2010 |
Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis KM Irrinki, K Mallilankaraman, RJ Thapa, HC Chandramoorthy, FJ Smith, ... Molecular and cellular biology, 2011 | 122 | 2011 |
Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells KS Minke, P Staib, A Puetter, I Gehrke, RK Gandhirajan, A Schlösser, ... European journal of haematology 82 (3), 165-175, 2009 | 105 | 2009 |
Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16 SK Sagwal, G Pasqual-Melo, Y Bodnar, RK Gandhirajan, S Bekeschus Cell Death & Disease 9 (12), 1179, 2018 | 97 | 2018 |
Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle S Mancarella, S Potireddy, Y Wang, H Gao, RK Gandhirajan, M Autieri, ... The FASEB Journal 27 (3), 893, 2013 | 90 | 2013 |
Targeting the WNT/β-catenin/TCF/LEF1 axis in solid and haematological cancers: multiplicity of therapeutic options I Gehrke, RK Gandhirajan, KA Kreuzer European Journal of Cancer 45 (16), 2759-2767, 2009 | 90 | 2009 |
Hyperhomocysteinemia and hyperglycemia induce and potentiate endothelial dysfunction via μ-calpain activation Z Cheng, X Jiang, M Pansuria, P Fang, J Mai, K Mallilankaraman, ... Diabetes 64 (3), 947-959, 2015 | 80 | 2015 |
Toxicity and immunogenicity in murine melanoma following exposure to physical plasma-derived oxidants S Bekeschus, K Rödder, B Fregin, O Otto, M Lippert, KD Weltmann, ... Oxidative medicine and cellular longevity 2017, 2017 | 76 | 2017 |
YAP-mediated mechanotransduction determines the podocyte’s response to damage MM Rinschen, F Grahammer, AK Hoppe, P Kohli, H Hagmann, O Kretz, ... Science signaling 10 (474), eaaf8165, 2017 | 68 | 2017 |
The vascular endothelial growth factor receptor tyrosine kinase inhibitors vatalanib and pazopanib potently induce apoptosis in chronic lymphocytic leukemia cells in vitro and … J Paesler, I Gehrke, RK Gandhirajan, A Filipovich, M Hertweck, ... Clinical cancer research 16 (13), 3390-3398, 2010 | 64 | 2010 |
Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic … I Gehrke, RK Gandhirajan, SJ Poll-Wolbeck, M Hallek, KA Kreuzer Molecular medicine 17, 619-627, 2011 | 62 | 2011 |
xCT (SLC7A11) expression confers intrinsic resistance to physical plasma treatment in tumor cells S Bekeschus, S Eisenmann, SK Sagwal, Y Bodnar, J Moritz, ... Redox Biology 30, 101423, 2020 | 53 | 2020 |
Cytochrome c oxidase inhibition and cold plasma-derived oxidants synergize in melanoma cell death induction RK Gandhirajan, K Rödder, Y Bodnar, G Pasqual-Melo, S Emmert, ... Scientific reports 8 (1), 12734, 2018 | 49 | 2018 |
Targeting malignant melanoma with physical plasmas G Pasqual-Melo, RK Gandhirajan, I Stoffels, S Bekeschus Clinical Plasma Medicine 10, 1-8, 2018 | 45 | 2018 |
Combination of gas plasma and radiotherapy has immunostimulatory potential and additive toxicity in murine melanoma cells in vitro G Pasqual-Melo, SK Sagwal, E Freund, RK Gandhirajan, B Frey, ... International Journal of Molecular Sciences 21 (4), 1379, 2020 | 41 | 2020 |
Activation of murine immune cells upon co-culture with plasma-treated B16F10 melanoma cells K Rödder, J Moritz, V Miller, KD Weltmann, HR Metelmann, ... Applied Sciences 9 (4), 660, 2019 | 40 | 2019 |
Wnt/β-catenin/LEF-1 signaling in chronic lymphocytic leukemia (CLL): a target for current and potential therapeutic options R K Gandhirajan, S J Poll-Wolbeck, I Gehrke, KA Kreuzer Current cancer drug targets 10 (7), 716-727, 2010 | 38 | 2010 |