| Stress adaptation in a pathogenic fungus AJP Brown, S Budge, D Kaloriti, A Tillmann, MD Jacobsen, Z Yin, IV Ene, ... Journal of Experimental Biology 217 (1), 144-155, 2014 | 301 | 2014 |
| Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast MD Leach, S Budge, L Walker, C Munro, LE Cowen, AJP Brown PLoS pathogens 8 (12), e1003069, 2012 | 136 | 2012 |
| Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance N Robbins, MD Leach, LE Cowen Cell reports 2 (4), 878-888, 2012 | 120 | 2012 |
| Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm‐blooded animals S Nicholls, MD Leach, CL Priest, AJP Brown Molecular microbiology 74 (4), 844-861, 2009 | 120 | 2009 |
| The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans D Sandai, Z Yin, L Selway, D Stead, J Walker, MD Leach, I Bohovych, ... MBio 3 (6), 10.1128/mbio. 00495-12, 2012 | 110 | 2012 |
| Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs MD Leach, E Klipp, LE Cowen, AJP Brown Nature Reviews Microbiology 10 (10), 693-704, 2012 | 107 | 2012 |
| Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans MD Leach, RA Farrer, K Tan, Z Miao, LA Walker, CA Cuomo, RT Wheeler, ... Nature communications 7 (1), 11704, 2016 | 104 | 2016 |
| Posttranslational modifications of proteins in the pathobiology of medically relevant fungi MD Leach, AJP Brown Eukaryotic cell 11 (2), 98-108, 2012 | 99 | 2012 |
| Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies EJ Polvi, X Li, TR O’Meara, MD Leach, LE Cowen Cellular and Molecular Life Sciences 72, 2261-2287, 2015 | 81 | 2015 |
| Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida … MD Leach, DA Stead, E Argo, DM MacCallum, AJP Brown Molecular microbiology 79 (6), 1574-1593, 2011 | 74 | 2011 |
| Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen … MD Leach, DA Stead, E Argo, AJP Brown Molecular biology of the cell 22 (5), 687-702, 2011 | 73 | 2011 |
| Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans MD Leach, KM Tyc, AJP Brown, E Klipp PLoS One 7 (3), e32467, 2012 | 71 | 2012 |
| Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans MD Leach, LE Cowen Eukaryotic cell 13 (8), 1077-1084, 2014 | 61 | 2014 |
| The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation JL Xie, L Qin, Z Miao, BT Grys, JDLC Diaz, K Ting, JR Krieger, J Tong, ... Nature communications 8 (1), 499, 2017 | 60 | 2017 |
| Functional genomic screening reveals core modulators of echinocandin stress responses in Candida albicans T Caplan, EJ Polvi, JL Xie, S Buckhalter, MD Leach, N Robbins, ... Cell reports 23 (8), 2292-2298, 2018 | 58 | 2018 |
| Surviving the heat of the moment: a fungal pathogens perspective MD Leach, LE Cowen PLoS pathogens 9 (3), e1003163, 2013 | 55 | 2013 |
| Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues JL Xie, N Grahl, T Sless, MD Leach, SH Kim, DA Hogan, N Robbins, ... PLoS genetics 12 (10), e1006405, 2016 | 46 | 2016 |
| Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 JL Xie, I Bohovych, EOY Wong, JP Lambert, AC Gingras, O Khalimonchuk, ... Microbial Cell 4 (10), 342, 2017 | 35 | 2017 |
| Functional divergence of Hsp90 genetic interactions in biofilm and planktonic cellular states S Diezmann, MD Leach, LE Cowen PLoS one 10 (9), e0137947, 2015 | 31 | 2015 |
| The relevance of heat shock regulation in fungal pathogens of humans AJP Brown, MD Leach, S Nicholls Virulence 1 (4), 330-332, 2010 | 31 | 2010 |
