Michelle Leach
Michelle Leach
University of Toronto
Verified email at abdn.ac.uk
TitleCited byYear
Stress adaptation in a pathogenic fungus
AJP Brown, S Budge, D Kaloriti, A Tillmann, MD Jacobsen, Z Yin, IV Ene, ...
Journal of Experimental Biology 217 (1), 144-155, 2014
Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast
MD Leach, S Budge, L Walker, C Munro, LE Cowen, AJP Brown
PLoS pathogens 8 (12), e1003069, 2012
Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm‐blooded animals
S Nicholls, MD Leach, CL Priest, AJP Brown
Molecular microbiology 74 (4), 844-861, 2009
The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans
D Sandai, Y Zhikang, L Selway, D Stead, J Walker, MD Leach, I Bohovych, ...
MBio 3 (6), e00495-12, 2012
Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs
MD Leach, E Klipp, LE Cowen, AJP Brown
Nature Reviews Microbiology 10 (10), 693, 2012
Posttranslational modifications of proteins in the pathobiology of medically relevant fungi
MD Leach, AJP Brown
Eukaryotic cell 11 (2), 98-108, 2012
Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance
N Robbins, MD Leach, LE Cowen
Cell reports 2 (4), 878-888, 2012
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans
MD Leach, RA Farrer, K Tan, Z Miao, LA Walker, CA Cuomo, RT Wheeler, ...
Nature communications 7, 11704, 2016
Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida …
MD Leach, DA Stead, E Argo, DM MacCallum, AJP Brown
Molecular microbiology 79 (6), 1574-1593, 2011
Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen …
MD Leach, DA Stead, E Argo, AJP Brown
Molecular biology of the cell 22 (5), 687-702, 2011
Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans
MD Leach, KM Tyc, AJP Brown, E Klipp
PLoS One 7 (3), e32467, 2012
Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans
MD Leach, LE Cowen
Eukaryotic cell 13 (8), 1077-1084, 2014
Surviving the heat of the moment: a fungal pathogens perspective
MD Leach, LE Cowen
PLoS pathogens 9 (3), e1003163, 2013
Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies
EJ Polvi, X Li, TR O’Meara, MD Leach, LE Cowen
Cellular and Molecular Life Sciences 72 (12), 2261-2287, 2015
Functional divergence of Hsp90 genetic interactions in biofilm and planktonic cellular states
S Diezmann, MD Leach, LE Cowen
PLoS one 10 (9), e0137947, 2015
The relevance of heat shock regulation in fungal pathogens of humans
AJP Brown, MD Leach, S Nicholls
Virulence 1 (4), 330-332, 2010
Signaling through Lrg1, Rho1 and Pkc1 governs Candida albicans morphogenesis in response to diverse cues
JL Xie, N Grahl, T Sless, MD Leach, SH Kim, DA Hogan, N Robbins, ...
PLoS genetics 12 (10), e1006405, 2016
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation
JL Xie, L Qin, Z Miao, BT Grys, JDLC Diaz, K Ting, JR Krieger, J Tong, ...
Nature communications 8 (1), 499, 2017
Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans
T Caplan, EJ Polvi, JL Xie, S Buckhalter, MD Leach, N Robbins, ...
Cell reports 23 (8), 2292-2298, 2018
To sense or die: mechanisms of temperature sensing in fungal pathogens
MD Leach, LE Cowen
Current Fungal Infection Reports 8 (2), 185-191, 2014
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