Howard McLeod

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Teri E. KleinStanford UniversityVerified email at stanford.edu
Alison Motsinger-ReifNational Institute of Environmental Health SciencesVerified email at nih.gov
Mark RatainLeon O. Jacobson Professor of Medicine, The University of ChicagoVerified email at uchicago.edu
Richard Goldberg MDProfessor emeritus, West Virginia UniversityVerified email at hsc.wvu.edu
Mary V. RellingSt. Jude Children's Research HospitalVerified email at stjude.org
William E EvansSt. Jude Children's Research HospitalVerified email at stjude.org
Daniel L HertzUniversity of MichiganVerified email at med.umich.edu
Brian F. GageProfessor of Medicine, Washington University in St. LouisVerified email at im.wustl.edu
LISA A. CAREY MD, ScM, FASCOUniversity of North Carolina Lineberger Comprehensive Cancer CenterVerified email at med.unc.edu
Russ B AltmanProfessor Stanford UniversityVerified email at stanford.edu
Deepak VooraDepartment of Veterans Affairs; Duke University Medical CenterVerified email at duke.edu
Jaap VerweijErasmus University Medical Center and Cancer Drug Development ForumVerified email at cddf.org
David Ofori-AdjeiProfessor of Medicine & Therapeutics, University of GhanaVerified email at noguchi.ug.edu.gh
David E. LanfearHenry Ford HospitalVerified email at hfhs.org
Todd C. KnepperAssociate Member, Precision Medicine, Moffitt Cancer CenterVerified email at moffitt.org
Jai N. Patel, PharmD, BCOP, CPPChair, Cancer Pharmacology & Pharmacogenomics, Levine Cancer Institute, Atrium HealthVerified email at atriumhealth.org
John SpertusSaint Luke's Mid America Heart Institute/University of Missouri - Kansas CityVerified email at umkc.edu
E Claire DeesUNCVerified email at med.unc.edu
Derek Van BoovenDirector Research Data, John P Hussman Insitute for Human Genomics, University of MiamiVerified email at med.miami.edu
Frank J. GonzalezNational Cancer InstituteVerified email at mail.nih.gov

Howard McLeod

Utah Tech University

Verified email at utahtech.edu - Homepage

personalized medicine cancer genomics Pharmacogenomics


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Pharmacogenomics—drug disposition, drug targets, and side effects WE Evans, HL McLeod New England Journal of Medicine 348 (6), 538-549, 2003	2450	2003
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose MJ Rieder, AP Reiner, BF Gage, DA Nickerson, CS Eby, HL McLeod, ... New England Journal of Medicine 352 (22), 2285-2293, 2005	1768	2005
Doxorubicin pathways: pharmacodynamics and adverse effects CF Thorn, C Oshiro, S Marsh, T Hernandez-Boussard, H McLeod, ... Pharmacogenetics and genomics 21 (7), 440, 2011	1745	2011
Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin BF Gage, C Eby, JA Johnson, E Deych, MJ Rieder, PM Ridker, ... Clinical Pharmacology & Therapeutics 84 (3), 326-331, 2008	949	2008
Genomics and drug response L Wang, HL McLeod, RM Weinshilboum New England Journal of Medicine 364 (12), 1144-1153, 2011	722	2011
Platinum neurotoxicity pharmacogenetics SR McWhinney, RM Goldberg, HL McLeod Molecular cancer therapeutics 8 (1), 10-16, 2009	679	2009
MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity MM Ameyaw, F Regateiro, T Li, X Liu, M Tariq, A Mobarek, N Thornton, ... Pharmacogenetics and Genomics 11 (3), 217-221, 2001	598	2001
Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs S Zhou, SY Chan, BC Goh, E Chan, W Duan, M Huang, HL McLeod Clinical pharmacokinetics 44, 279-304, 2005	581	2005
UGT1A1* 28 genotype and irinotecan-induced neutropenia: dose matters JM Hoskins, RM Goldberg, P Qu, JG Ibrahim, HL McLeod Journal of the National Cancer Institute 99 (17), 1290-1295, 2007	566	2007
Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer Y Wang, T Jatkoe, Y Zhang, MG Mutch, D Talantov, J Jiang, HL McLeod, ... Journal of clinical oncology 22 (9), 1564-1571, 2004	563	2004
Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia HL McLeod, EY Krynetski, MV Relling, WE Evans Leukemia 14 (4), 567-572, 2000	557	2000
PI3K/Akt/mTOR pathway as a target for cancer therapy D Morgensztern, HL McLeod Anti-cancer drugs 16 (8), 797-803, 2005	552	2005
Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism GJ Peters, HHJ Backus, S Freemantle, B Van Triest, G Codacci-Pisanelli, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3 …, 2002	477	2002
Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine AJ Black, HL McLeod, HA Capell, RH Powrie, LK Matowe, SC Pritchard, ... Annals of internal medicine 129 (9), 716-718, 1998	473	1998
Carbamazepine, HLA-B1502* and risk of Stevens–Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations PB Ferrell, HL McLeod Future Medicine Ltd 9 (10), 1543-1546, 2008	472	2008
Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing: 2017 update U Amstutz, LM Henricks, SM Offer, J Barbarino, JHM Schellens, JJ Swen, ... Clinical Pharmacology & Therapeutics 103 (2), 210-216, 2018	470	2018
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. X Wei, HL McLeod, J McMurrough, FJ Gonzalez, P Fernandez-Salguero The Journal of clinical investigation 98 (3), 610-615, 1996	464	1996
The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations ESR Collie-Duguid, J Sludden, T Li, HL McLeod Pharmacogenetics and Genomics 9 (1), 37-42, 1999	449	1999
Strategies for enzyme/prodrug cancer therapy G Xu, HL McLeod Clinical Cancer Research 7 (11), 3314-3324, 2001	445	2001
The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin‐Induced Myopathy: 2014 Update LB Ramsey, SG Johnson, KE Caudle, CE Haidar, D Voora, RA Wilke, ... Clinical Pharmacology & Therapeutics 96 (4), 423-428, 2014	436	2014

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